The effect of stimulus pulse duration on selectivity of neural stimulation
The effect of stimulus pulse duration on selectivity of neural stimulation
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DOI：
10.1109/10.481985
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发表时间：
1996-02-01
影响因子：
4.6
通讯作者：
Mortimer, JT
中科院分区：
文献类型：
--
作者：
Grill, WM;Mortimer, JT
刺激参数的选择是神经假体系统设计中的重要考虑因素。本研究的目的是确定矩形刺激脉宽（PW）对周围神经刺激选择性的影响。使用哺乳动物有髓神经纤维的电缆模型的计算机模拟表明，较短的PW增加了位于离电极不同距离处的纤维的阈值电流之间的差异。由外周神经刺激产生的关节扭矩的实验测量表明，较短的PW在溢出之前产生较大的扭矩，并且在阈值和溢出之间产生较大的电流动态范围。因此，较短的PW的允许更多的空间选择性刺激的神经纤维，被动电缆模型的响应分析不同的持续时间的刺激表明，PW依赖的贡献分布源膜极化占所观察到的选择性的差异。
Choice of stimulus parameters is an important consideration in the design of neural prosthetic systems. The objective of this study was to determine the effect of rectangular stimulus pulsewidth (PW) on the selectivity of peripheral nerve stimulation. Computer simulations using a cable model of a mammalian myelinated nerve fiber indicated that shorter PW's increased the difference between the threshold currents of fibers lying at different distances from an electrode, Experimental measurements of joint torque generated by peripheral nerve stimulation demonstrated that shorter PW's generated larger torques before spillover and created a larger dynamic range of currents between threshold and spillover. Thus, shorter PW's allowed more spatially selective stimulation of nerve fibers, Analysis of the response of a passive cable model to different duration stimuli indicated that PW dependent contributions of distributed sources to membrane polarization accounted for the observed differences in selectivity.