Cholangitis as a late complication in long-term survivors after surgery for biliary atresia
Cholangitis as a late complication in long-term survivors after surgery for biliary atresia
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DOI：
10.1016/j.jpedsurg.2004.08.021
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发表时间：
2004-12-01
影响因子：
2.4
通讯作者：
Ohi, R
中科院分区：
文献类型：
--
作者：
Nio, M;Sano, N;Ohi, R
背景/目的：一项回顾性分析，以评估诊断性成像（DI）的效用，治疗的疗效，并在长期生存的胆道闭锁手术后的晚期胆管炎的结局：61例存活无肝移植（LTx）超过20年被分为2组，根据胆管炎是否在20岁后发展。比较两组梗阻类型、初次手术年龄、早期胆管炎并发症等临床因素。DI，如计算机断层扫描和磁共振成像，胆管炎治疗后的临床过程中，目前的状态patients.Results：13例胆管炎后，年龄20。两组间研究的临床因素无统计学差异。10例晚期胆管炎患者出现肝内胆管扩张、肝纤维化等异常DI改变。1例患者死亡，2例最终接受LTx。其余10例患者，包括4个正常或接近正常的肝功能生存没有LTx.Conclusions：虽然大多数患者有潜在的诱发因素，如肝内胆管扩张胆管炎，少数患者意外胆管炎没有这样的异常结果后，一个优秀的，长期的术后过程。(C)2004年爱思唯尔公司All rights reserved.
Background/Purpose: A retrospective review was performed to assess the utility of diagnostic imaging (DI), efficacy of treatment, and outcome of late cholangitis in long-term survivors after surgery for biliary atresia.Methods: Sixty-one patients surviving without liver transplantation (LTx) for more than 20 years were divided into 2 groups depending on whether cholangitis developed after age 20. Clinical factors including the type of obstruction, the age at the initial operation, and the early complication with cholangitis were compared between the 2 groups. DI such as computed tomography scan and magnetic resonance imaging, clinical courses after treatment of cholangitis, and current status of the patients were also evaluated.Results: Thirteen patients had cholangitis after age 20. There was no statistical difference in the clinical factors studied between the 2 groups. Abnormal DI findings including dilatation of intrahepatic bile ducts and hepatic fibrosis were seen in 10 patients with late cholangitis. One patient died, and 2 ultimately underwent LTx. The remaining 10 patients including 4 with normal or near-normal liver function have survived without LTx.Conclusions: Although the majority of the patients had potential predisposing factors for cholangitis such as dilatation of intrahepatic bile ducts, a few patients unexpectedly had cholangitis without such abnormal findings after an excellent, long-term postoperative course. (C) 2004 Elsevier Inc. All rights reserved.