Roles of YAP in mediating endothelial cell junctional stability and vascular remodeling.
Roles of YAP in mediating endothelial cell junctional stability and vascular remodeling.
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DOI：
10.5483/bmbrep.2015.48.8.146
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发表时间：
2015-08
期刊：
影响因子：
3.8
通讯作者：
Kwon YG
中科院分区：
文献类型：
--
作者：
Choi HJ;Kwon YG
血管生成是一个复杂的过程，涉及各种细胞与细胞相互作用的动态相互作用。由生长因子、炎性细胞因子或血流动力学应激调节的内皮细胞相互作用对于平衡血管静止和激活至关重要。是相关蛋白（雅普）是Hippo信号的一种效应子，在维持细胞内环境稳定中起重要作用。然而，其在内皮细胞中的血管生成调节作用仍然相对未被探索。我们证明了雅普在血管内皮细胞中的关键作用，并阐明了参与雅普血管生成调控的潜在分子机制。雅普表达于内皮细胞连接相对疏松的血管生成活跃区域。因此，雅普的亚细胞定位和活性受VE-钙粘蛋白介导的PI 3 K/Akt信号通路的调节。因此，雅普通过血管生成素-2表达调节内皮发芽。这些结果为通过雅普协调内皮连接稳定性和血管生成激活的模型提供了一种见解。[BMB报告2015; 48（8）：429-430]
Angiogenesis is a complex process involving dynamic interaction of various cell to cell interactions. Endothelial cell interactions regulated by growth factors, inflammatory cytokines, or hemodynamic stress are critical for balancing vascular quiescence and activation. Yes-associated protein (YAP), an effector of Hippo signaling, is known to play significant roles in maintaining cellular homeostasis. However, its role in endothelial cells for angiogenic regulation remains relatively unexplored. We demonstrated the critical role of YAP in vascular endothelial cells and elucidated the underlying molecular mechanisms involved in angiogenic regulation of YAP. YAP was expressed in active angiogenic regions where endothelial cell junctions were relatively loosened. Consistently, YAP subcellular localization and activity were regulated by VE-cadherin-mediated PI3K/Akt pathway. YAP thereby regulated endothelial sprouting via angiopoietin-2 expression. These results provide an insight into a model of coordinating endothelial junctional stability and angiogenic activation through YAP. [BMB Reports 2015; 48(8): 429-430]