History of treated hypertension and diabetes mellitus and risk of renal cell cancer
History of treated hypertension and diabetes mellitus and risk of renal cell cancer
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DOI：
10.1093/annonc/mdl438
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发表时间：
2007-03-01
影响因子：
50.5
通讯作者：
La Vecchia, C.
中科院分区：
文献类型：
--
作者：
Zucchetto, A.;Dal Maso, L.;La Vecchia, C.
背景：据报道，高血压患者患肾细胞癌（RCC）的风险增加。这种关联是否会因性别、吸烟、肥胖或肾细胞癌临床表现而异尚不清楚。糖尿病和肾细胞癌之间的联系的结果是inconclusion.Patients和方法：我们进行了一项意大利多中心病例对照研究，包括767（494名男性，273名女性）肾细胞癌的事件的情况下，80岁以下，和1534医院控制，频率匹配的情况下。多元逻辑回归模型，条件中心，性别和年龄，并调整期间的采访，教育，吸烟，和身体质量被用来估计比值比（OR）。结果：与从未接受治疗的受试者相比，患者治疗的高血压病史[OR = 1.7，95%置信区间（CI）1.4-2.1]报告的RCC的风险过高。这种模式在性别、教育、吸烟习惯、体重、肿瘤组织学类型、分期或分级的不同分层中得到证实。在这一人群中，肾细胞癌对治疗后高血压的归因风险为16%。糖尿病史的危险性轻微增加（OR = 1.3，95%CI 0.9-1.7）。结论：高血压与肾细胞癌的发生可能存在直接相关性。
Background: An increased risk of renal cell cancer (RCC) has been reported in subjects with hypertension. Whether this association may vary according to sex, smoking, obesity, or RCC clinical presentation is unclear. Results on the link between diabetes mellitus and RCC are inconclusive.Patients and methods: We conducted an Italian multicenter case-control study, including 767 (494 men, 273 women) incident cases of RCC, under 80 years of age, and 1534 hospital controls, frequency-matched to cases. Multiple logistic regression models, conditioned to center, sex, and age, and adjusted for period of interview, education, smoking, and body mass were used to estimate odds ratios (OR).Results: Compared with subjects never treated, patients with a history of treated hypertension [OR = 1.7, 95% confidence interval (CI) 1.4-2.1] reported an excess risk of RCC. This pattern was confirmed in different strata of sex, education, smoking habits, body mass, tumor histological type, stage, or grade. The attributable risk of RCC for treated hypertension in this population was 16%. A slight, nonsignificant increased risk was found for history of diabetes mellitus (OR = 1.3, 95% CI 0.9-1.7).Conclusion: A possible causal role of hypertension in renal cell carcinogenesis is supported by the consistency of the direct association.