Quantitative imaging of coronary blood flow.
Quantitative imaging of coronary blood flow.
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DOI：
10.3402/nano.v1i0.5110
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Bassingthwaighte JB
中科院分区：
文献类型：
--
作者：
Alessio AM;Butterworth E;Caldwell JH;Bassingthwaighte JB
正电子发射断层扫描（PET）是一种核医学成像模式，基于正电子发射放射性示踪剂的管理，示踪剂的分布和动力学成像，以及生理事件及其对健康和疾病的意义的解释。PET成像在20世纪70年代被引入，放射性示踪剂和检测系统的许多进步使这种模式能够解决各种各样的临床任务，例如癌症的检测，阿尔茨海默病的分期和冠状动脉疾病（CAD）的评估。这篇综述描述了PET成像所需过程的逻辑和物流，并讨论了其在指导CAD治疗中的应用。最后，我们概述了纳米粒子作为PET成像剂的前景和局限性。
Positron emission tomography (PET) is a nuclear medicine imaging modality based on the administration of a positron-emitting radiotracer, the imaging of the distribution and kinetics of the tracer, and the interpretation of the physiological events and their meaning with respect to health and disease. PET imaging was introduced in the 1970s and numerous advances in radiotracers and detection systems have enabled this modality to address a wide variety of clinical tasks, such as the detection of cancer, staging of Alzheimer's disease, and assessment of coronary artery disease (CAD). This review provides a description of the logic and the logistics of the processes required for PET imaging and a discussion of its use in guiding the treatment of CAD. Finally, we outline prospects and limitations of nanoparticles as agents for PET imaging.