Vestibular compensation in glutamate receptor delta-2 subunit knockout mice: dynamic property of vestibulo-ocular reflex
Vestibular compensation in glutamate receptor delta-2 subunit knockout mice: dynamic property of vestibulo-ocular reflex
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DOI：
10.1007/s00405-003-0644-5
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发表时间：
2004-02-01
影响因子：
2.6
通讯作者：
Hirano, T
中科院分区：
文献类型：
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作者：
Murai, N;Tsuji, J;Hirano, T
谷氨酸受体δ亚家族的δ-2亚基选择性地定位于小脑浦肯野细胞。Delta-2基因敲除小鼠在浦肯野细胞突触形成方面存在缺陷，以及小脑长期抑郁。为了阐明浦肯野细胞周围的神经传递在前庭代偿中的作用，测量了delta-2基因敲除小鼠单侧前庭传入阻滞前后前庭眼反射的增益和相位。单侧内耳损伤后，基因敲除小鼠和野生型小鼠的增重均下降，然后恢复。然而，恢复VOR增益后，单侧前庭传入阻滞基因敲除小鼠比野生型小鼠慢。在术后第1周和第2周之间的时间段内，敲除小鼠显示出比野生型小鼠更低的VOR增益。结果表明，小脑是必要的前庭眼反射增益的增加在部分补偿阶段的前庭代偿后，单侧前庭传入神经切断。
The delta-2 subunit of the glutamate receptor delta subfamily is selectively localised in cerebellar Purkinje cells. Delta-2 knock-out mice have defects in Purkinje cell synapse formation, as well as cerebellar long- term depression. In order to elucidate the roles of neural transmission around Purkinje cells in vestibular compensation, the gain and phase of the vestibulo-ocular reflex were measured before and after unilateral vestibular deafferentiation in delta-2 knock-out mice. After unilateral injury of the inner ear, gain decreased and then recovered in both knock-out mice and wild-type mice. However, recovery of VOR gain after unilateral vestibular deafferentiation was slower in knock-out mice than in wild-type mice. The knock-out mice displayed lower VOR gain than wild-type mice during the period between the 1st and the 2nd postoperative weeks. The results suggest that the cerebellum is necessary for augmentation of vestibulo-ocular reflex gain during the partially compensated stage of vestibular compensation after unilateral vestibular deafferentiation.