Keeping replication on par with division in Bacillus.
Keeping replication on par with division in Bacillus.
复制标题
保持芽孢杆菌的复制与分裂。
DOI：
10.1111/mmi.14338
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发表时间：
2019
影响因子：
3.6
通讯作者：
Levin,PetraA
中科院分区：
文献类型：
--
作者：
Haeusser,DanielP;Levin,PetraA
在空间上，分裂位点选择是细菌生理学中最精确控制的过程之一。尽管它对产生适当大小的有活力的子细胞具有明显的重要性，但分裂位点选择的潜在机制在很大程度上仍然是神秘的。他们推翻了以前的模型，包括他们自己的模型，发现参与染色体重塑的两个因素-ParB样蛋白Spo 0 J和类核相关蛋白Noc -共同协调DNA复制的早期步骤，并在革兰氏阳性细菌枯草芽孢杆菌中建立中间分裂位点。
Spatially, division site selection is one of the most precisely controlled processes in bacterial physiology. Despite its obvious importance to the production of properly sized, viable daughter cells, the mechanisms underlying division site selection have remained largely mysterious.Molecular Microbiology, Hajduket al. provide new insight into this essential process. Overturning previous models, including one of their own, they discover that two factors involved in chromosome remodeling – the ParB‐like protein Spo0J, and the nucleoid‐associated protein Noc – work together to coordinate early steps in DNA replication with establishment of a medial division site in the Gram‐positive bacterium,Bacillus subtilis.