THE FATIGUE SEVERITY SCALE - APPLICATION TO PATIENTS WITH MULTIPLE-SCLEROSIS AND SYSTEMIC LUPUS-ERYTHEMATOSUS
THE FATIGUE SEVERITY SCALE - APPLICATION TO PATIENTS WITH MULTIPLE-SCLEROSIS AND SYSTEMIC LUPUS-ERYTHEMATOSUS
复制标题
DOI：
10.1001/archneur.1989.00520460115022
复制
发表时间：
1989-10-01
影响因子：
--
通讯作者：
STEINBERG, AD
中科院分区：
文献类型：
--
作者：
KRUPP, LB;LAROCCA, NG;STEINBERG, AD
疲劳是多种医学和神经系统疾病中的一个突出的致残症状。为了促进这一领域的研究，我们开发了疲劳严重程度量表，对其进行了内部一致性和有效性测试，并用它来比较两种慢性疾病：系统性红斑狼疮和多发性硬化症的疲劳情况。对 25 名多发性硬化症患者、29 名系统性红斑狼疮患者和 20 名健康成年人使用疲劳严重程度量表显示，疲劳严重程度量表内部一致，与视觉模拟测量值相关性良好，与患者的对照明显不同，并且可以检测临床预测的疲劳随时间的变化。与对照组相比，疲劳对多发性硬化症和系统性红斑狼疮患者的日常生活产生更大的有害影响。结果进一步表明，疲劳在很大程度上与自我报告的抑郁症状无关，并且有几个特征可以区分多发性硬化症伴随的疲劳和系统性红斑狼疮伴随的疲劳。这项研究展示了（1）测量疲劳严重程度的量表的临床和研究应用，以及（2）有助于识别区分两种慢性疾病之间疲劳的特征。
Fatigue is a prominent disabling symptom in a variety of medical and neurological disorders. To facilitate research in this area, we developed a fatigue severity scale, subjected it to tests of internal consistency and validity, and used it to compare fatigue in two chronic conditions: systemic lupus erythematosus and multiple sclerosis. Administration of the fatigue severity scale to 25 patients with multiple sclerosis, 29 patients with systemic lupus erythematosus, and 20 healthy adults revealed that the fatigue severity scale was internally consistent, correlated well with visual analogue measures, clearly differentiated controls from patients, and could detect clinically predicted changes in fatigue over time. Fatigue had a greater deleterious impact on daily living in patients with multiple sclerosis and systemic lupus erythematosus compared with controls. The results further showed that fatigue was largely independent of self-reported depressive symptoms and that several characteristics could differentiate fatigue that accompanies multiple sclerosis from fatigue that accompanies systemic lupus erythematosus. This study demonstrates (1) the clinical and research applications of a scale that measures fatigue severity and (2) helps to identify features that distinguish fatigue between two chronic medical disorders.