Enhanced food intake regulatory responses after a glucose drink in hyperinsulinemic men
Enhanced food intake regulatory responses after a glucose drink in hyperinsulinemic men
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DOI：
10.1038/sj.ijo.0803565
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发表时间：
2007-08-01
影响因子：
4.9
通讯作者：
Anderson, G. H.
中科院分区：
文献类型：
--
作者：
Abou Samra, R.;Wolever, T. M. S.;Anderson, G. H.
目的：研究葡萄糖饮料对高胰岛素血症对男性食物摄入量、血浆葡萄糖浓度和食物摄入调节激素的影响。设计：葡萄糖饮料对食物摄入调节影响的横断面临床干预研究。（体重指数（BMI）25.3 ± 0.6;年龄41.4 ± 2.4）和32名高胰岛素血症（HI）男性（BMI 29.5 +/- 0.6;年龄43.4 +/- 2.6）。食物摄入量从比萨饼餐后1小时测量受试者消耗无热量的甜味饮料或含葡萄糖的饮料（75克/300毫升）在两个场合随机顺序。结果：HI组和NI组的空腹胰岛素水平分别为65 +/- 3（平均+/- s.e.m.），HI组和NI组的空腹胰岛素水平分别为65 +/- 3（平均+/- s.e.m.）和26 +/- 1.5 pmol/l。葡萄糖饮料减少了比萨饼餐时的食物摄入量（P < 0.01），但HI男性（-9.7 +/-4.1%）比NI男性（-5.4 +/-3.4%）减少得更多（P = 0.06）。HI男性在葡萄糖饮料后血浆胰岛素和胆囊收缩素（CCK）的增加更大，血浆瘦素浓度更高，而ghrelin和脂联素浓度低于NI男性（P < 0.05）。结论：这些结果支持流行病学数据，表明高胰岛素血症，至少在早期阶段，可能提供抵抗体重增加，可能是通过控制食物摄入的生理机制。
Objective: To determine the effect of hyperinsulinemia on food intake and plasma concentrations of glucose and food intake regulatory hormones in men after a glucose drink.Design: Cross-sectional clinical intervention study of the effect of a glucose drink on food intake regulation.Subjects: Thirty-three normoinsulinemic (NI) (body mass index (BMI) 25.3 +/- 0.6; age 41.4 +/- 2.4) and 32 hyperinsulinemic (HI) men (BMI 29.5 +/- 0.6; age 43.4 +/- 2.6).Measurements: Food intake was measured from a pizza meal 1 h after subjects consumed either a noncaloric sweetened drink or a glucose-containing drink (75g/300 ml) in random order on two occasions. On another occasion, blood samples were taken every 30 min for 2 h after the glucose drink.Results: Fasting insulin in the HI and NI men was 65 +/- 3 (mean +/- s.e.m.) and 26 +/- 1.5 pmol/l, respectively. Food intake at the pizza meal was reduced by the glucose drink (P < 0.01), but more so in HI (-9.7 +/- 4.1 %) than NI men (-5.4 +/- 3.4 %) (P = 0.06). The increase in plasma insulin and cholecystokinin (CCK) after the glucose drink was greater and the plasma concentrations of leptin were higher, and ghrelin and adiponectin were lower in HI men than in NI men (P < 0.05).Conclusion: These results support epidemiological data suggesting that hyperinsulinemia, at least in the early stages, may provide resistance to weight gain, possibly through physiological mechanisms of food intake control.