Correlation of quantitative bone marrow and blood cultures in AIDS patients with disseminated Mycobacterium avium complex infection.
Correlation of quantitative bone marrow and blood cultures in AIDS patients with disseminated Mycobacterium avium complex infection.
复制标题
患有播散性鸟分枝杆菌复合体感染的艾滋病患者骨髓定量和血培养的相关性。
DOI：
10.1086/314865
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Muth,K
中科院分区：
文献类型：
--
作者：
Hafner,R;Inderlied,CB;Peterson,DM;Wright,DJ;Standiford,HC;Drusano,G;Muth,K
本文研究了人类免疫缺陷病毒（HIV）感染者治疗前和治疗中血液和骨髓鸟分枝杆菌复合群（MAC）感染的关系。从17名新检测到MAC菌血症的患者中获得基线定量培养物。获得连续的血液培养物，并在4或8周时获得第二份骨髓样品。在基线时，骨髓核心样本中的中位MAC负荷比血液高3 log 10。骨髓MAC载量范围较广（866 ~ 847，315 cfu/g），血液MAC载量与骨髓核心样本MAC载量无明显相关性。来自7名受试者的双侧骨髓活检样本中的MAC负荷高度相关。在治疗过程中，血液和骨髓中的MAC负荷以相似的速率下降，但血液在骨髓之前被消毒。存活时间与初始骨髓核心MAC负荷呈负相关，但与血液MAC负荷无关。当组织MAC负荷较低时开始治疗可能会增加有利临床结局的可能性。
The relationship betweenMycobacterium aviumcomplex (MAC) infection of blood and bone marrow was studied in human immunodeficiency virus—infected patients before and during treatment. Quantitative cultures were obtained at baseline from 17 persons with newly detected MAC bacteremia. Serial blood cultures were obtained, and a second bone marrow sample was obtained at 4 or 8 weeks. At baseline, the median MAC load in bone marrow core samples was 3 log10higher than in blood. Bone marrow MAC loads ranged widely (866–847,315 cfu/g), and no significant correlation was found between MAC load in blood and that in bone marrow core samples. MAC loads in bilateral bone marrow biopsy samples from 7 subjects were highly correlated. MAC loads declined in blood and bone marrow at similar rates during therapy, but blood was sterilized before bone marrow. Length of survival was inversely associated with initial bone marrow core MAC load but not with blood MAC load. Initiation of treatment when tissue MAC load is low may increase the likelihood of favorable clinical outcome.