Mutations in the epidermal growth factor receptor gene are linked to smoking-independent, lung adenocarcinoma.
Mutations in the epidermal growth factor receptor gene are linked to smoking-independent, lung adenocarcinoma.
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DOI：
10.1038/sj.bjc.6602707
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发表时间：
2005-08-08
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
表皮生长因子受体(EGFR)突变是预测EGFR抑制剂治疗肺癌有效性的潜在指标。虽然据报道，EGFR突变在不吸烟的日本腺癌患者中发生的频率很高，但其确切的性质尚未完全阐明。我们检测了在京都大学医院接受肺癌切除术的154例患者的肿瘤标本中EGFR基因外显子18-21的突变及其与临床病理因素和其他基因改变的相关性。60个肿瘤(39.0%)有表皮生长因子受体突变，均为腺癌。在108例腺癌患者中，EGFR突变在非吸烟者中的发生率高于吸烟者或现在吸烟者(分别为83.0%、50.0%、15.2%)，在女性患者中的突变频率高于男性(76.3%对34.0%)，在有细支气管肺泡成分的肿瘤中的频率高于不含细支气管肺泡成分的肿瘤(78.9%vs42.9%)，在高或中分化肿瘤中的频率高于低分化肿瘤(72.0%、64.4%、34.2%)。携带EGFR突变的肿瘤没有任何K-ras密码子12突变，这是众所周知的与吸烟相关的基因突变。综上所述，携带EGFR基因突变的腺癌具有与吸烟无关的独特临床病理特征。表皮生长因子受体突变可能在吸烟非依赖性腺癌的发展中起关键作用。
Epidermal growth factor receptor (EGFR) mutations are a potential predictor of the effectiveness of EGFR inhibitors for the treatment of lung cancer. Although EGFR mutations were reported to occur with high frequency in nonsmoking Japanese adenocarcinoma patients, the exact nature has not been fully elucidated. We examined EGFR gene mutations within exons 18–21 and their correlations to clinico-pathological factors and other genetic alterations in tumour specimens from 154 patients who underwent resection for lung cancer at Kyoto University Hospital. Epidermal growth factor receptor mutations were observed in 60 tumours (39.0%), all of which were adenocarcinoma. Among the patients with adenocarcinoma (n=108), EGFR mutations were more frequently observed in nonsmokers than former smokers or current smokers (83.0, 50.0, 15.2%, respectively), in women than men (76.3 vs 34.0%), in tumours with bronchio-alveolar component than those without bronchio-alveolar component (78.9 vs 42.9%), and in well or moderately differentiated tumours than poorly differentiated tumours (72.0, 64.4, 34.2%). No tumours with EGFR mutations had any K-ras codon 12 mutations, which were well-known smoking-related gene mutations. In conclusion, adenocarcinomas with EGFR mutation had a distinctive clinico-pathological feature unrelated to smoking. Epidermal growth factor receptor mutations may play a key role in the development of smoking-independent adenocarcinoma.
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影响因子：
158.5
作者：
Lynch, TJ;Bell, DW;Haber, DA
通讯作者：
Haber, DA
DOI：
10.1073/pnas.93.18.9821
发表时间：
1996-09-03
影响因子：
11.1
作者：
Herman, JG;Graff, JR;Baylin, SB
通讯作者：
Baylin, SB
DOI：
10.1073/pnas.86.8.2766
发表时间：
1989-04-01
影响因子：
11.1
作者：
ORITA, M;IWAHANA, H;SEKIYA, T
通讯作者：
SEKIYA, T
影响因子：
45.3
作者：
Han, SW;Kim, TY;Kim, NK
通讯作者：
Kim, NK
中国肺癌患者 EGFR 激酶结构域突变的鉴定：对癌症靶向治疗的启示
影响因子：
44.1
作者：
Qin, BM;Chen, X;Pei, DQ
通讯作者：
Pei, DQ