Bridging spinal cord injuries.
Bridging spinal cord injuries.
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DOI：
10.1186/jbiol89
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发表时间：
2008-10-15
影响因子：
--
通讯作者：
Fawcett JW
中科院分区：
文献类型：
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作者：
Fawcett JW
脊髓损伤修复的一个策略是制造支持轴突再生的细胞桥。然而，桥接细胞往往无法与宿主组织结合，可能会导致疼痛敏感度增加。最近的研究已经测试了两种形式的祖细胞来源的星形胶质细胞之间的桥接。一种类型整合、抑制疤痕形成并促进轴突再生，而另一种非常相似的类型，发表在《生物学杂志》上，不支持再生，并增加疼痛敏感性。
One strategy for spinal cord injury repair is to make cellular bridges that support axon regeneration. However, the bridging cells often fail to integrate with host tissue and may lead to increased pain sensitivity. Recent work has tested bridging with two forms of progenitor-derived astrocyte. One type integrates, suppresses scar formation and promotes axon regeneration, whereas another very similar type, reported in Journal of Biology, does not support regeneration and increases pain sensitivity.