Molecular Genotyping and Epidemiology of Measles Virus Transmission in the World Health Organization European Region, 2007-2009
Molecular Genotyping and Epidemiology of Measles Virus Transmission in the World Health Organization European Region, 2007-2009
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DOI：
10.1093/infdis/jir101
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发表时间：
2011-07-15
影响因子：
6.4
通讯作者：
Gavrilin, Eugene
中科院分区：
文献类型：
--
作者：
Mankertz, Annette;Mulders, Mick N.;Gavrilin, Eugene
背景2002年，世界卫生组织（世卫组织）通过了到2010年在欧洲区域消除麻疹的目标。消灭麻疹的定义是中断本土麻疹病毒（MV）的传播。通过调查报告的病例和暴发，研究了世卫组织欧洲区域MV传播的分子流行病学，以监测该区域实现消除麻疹目标的进展情况。国家和区域实验室在世卫组织欧洲区域2007年至2009年期间检测到的MV进行了分子表征。为了记录本地传播和输入到该地区，我们分析了成员国报告的麻疹暴发的基因分型结果和流行病学数据。自2007年以来，世卫组织欧洲区域未报告MV基因型D6，表明其传播链已被中断，而其他几种MV基因型仍在传播。虽然一些欧洲国家已经阻断了本土MV传播，但基因分型显示3个地方性MV传播链在其他国家重新建立。世卫组织欧洲区域2010年目标将无法实现，因为MV的本土传播尚未中断。随着该地区开始记录其消除核查过程以监测实现目标的进展，各国将需要确保在所有麻疹疫情中进行基因分型。
Background. In 2002, the World Health Organization (WHO) adopted a goal to eliminate measles in the European Region by 2010. Measles elimination is defined as the interruption of indigenous measles virus (MV) transmission. The molecular epidemiology of MV transmission in the WHO European Region was studied through the investigation of reported cases and outbreaks to monitor the region's progress toward its measles elimination goal.Methods. National and regional laboratories performed molecular characterization of MV detected between 2007 and 2009 in the WHO European Region. To document indigenous transmission and importations into the region, we analyzed genotyping results and epidemiological data on measles outbreaks reported by the member states.Results. Since 2007, MV genotype D6 has not been reported in the WHO European Region, suggesting that its chains of transmission have been interrupted, whereas several other MV genotypes are still circulating. Although several European countries have already interrupted indigenous MV transmission, genotyping showed that 3 endemic MV transmission chains have been reestablished in other countries.Conclusions. The WHO European Region 2010 goal will not be met, as indigenous transmission of MV has not been interrupted. As the region begins to document its process of elimination verification to monitor progress toward the goal, countries will need to ensure that genotyping is performed in all measles outbreaks.