Dose-dependent effects of estradiol benzoate on 5-HT1A receptor agonist action
Dose-dependent effects of estradiol benzoate on 5-HT1A receptor agonist action
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DOI：
10.1016/s0006-8993(98)00238-8
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发表时间：
1998-06-15
期刊：
影响因子：
2.9
通讯作者：
Uphouse, L
中科院分区：
文献类型：
--
作者：
Jackson, A;Uphouse, L
The lordosis-inhibiting effects of the 5-HT1A receptor agonist, (+/-)8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), were examined in ovariectomized rats, hormone primed with 2.5, 7.5, or 25 mu g estradiol benzoate plus 500 mu g progesterone. 8-OH-DPAT (50, 100 or 200 ng per bilateral site) infused into the ventromedial nucleus of the hypothalamus (VMN), inhibited lordosis behavior in all hormone-treated conditions. However, animals primed with 2.5 mu g estradiol benzoate were significantly more affected by the infusion than rats primed with 7.5 or 25 mu g of the hormone. These findings strengthen prior speculations that 5-HT1A receptor function is modulated by estrogen. (C) 1998 Elsevier Science B.V. All rights reserved.
