Visible-Light-Mediated Radical Aryldifluoroacetylation of Alkynes with Ethyl Bromodifluoroacetate for the Synthesis of 3-Difluoroacetylated Coumarins
Visible-Light-Mediated Radical Aryldifluoroacetylation of Alkynes with Ethyl Bromodifluoroacetate for the Synthesis of 3-Difluoroacetylated Coumarins
复制标题
可见光介导的炔烃与溴二氟乙酸乙酯的自由基芳基二氟乙酰化用于合成 3-二氟乙酰化香豆素
DOI：
10.1021/acs.joc.5b00305
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发表时间：
2015-05-01
影响因子：
3.6
通讯作者：
Ji, Baoming
中科院分区：
文献类型：
--
作者：
Fu, Weijun;Zhu, Mei;Ji, Baoming
研究了一种以溴代氟乙酸乙酯为催化剂，在可见光催化下芳基二氟乙酰化炔烃合成3-二氟乙酰化香豆素的方法。该反应允许通过提出的串联自由基环化过程直接形成C-sp(2)-CF2COOEt和C-C键。
A mild and efficient method for the synthesis of 3-difluoroacetylated coumarins through visible-light-promoted aryldifluoroacetylation of alkynes with ethyl bromodifluoroacetate has been developed. The reaction allows the direct formation of C-sp(2)-CF2COOEt and C-C bonds via a proposed tandem radical cyclization process.