Non-invasive imaging of ventricular activation during pacing and arrhythmia: Methods and validation.
Non-invasive imaging of ventricular activation during pacing and arrhythmia: Methods and validation.
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起搏和心律失常期间心室激动的无创成像：方法和验证。
DOI：
10.1109/embc.2016.7590653
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
BinHe
中科院分区：
文献类型：
--
作者：
LongYu;Pogwizd,Steven;BinHe
心血管疾病仍然是全世界的主要杀手。每年，仅在美国就报告了大约40万例心脏骤停病例。临床上，射频消融术已广泛应用于室性心律失常的治疗。非侵入性方法已被证明能够提供关于肿瘤发生的重要信息，并可能有助于临床实践。在这项工作中，我们开发并验证了一种新的时间稀疏成像方法，心脏电稀疏成像（CESI）。计算机模拟和动物验证结果表明，CESI方法能够利用细胞电生理学的时间稀疏特性，提高成像的准确性和鲁棒性。总体而言，在人类逼真模拟上实现了0.8的CC、0.2的RE和7 mm的LE（定位误差），并且在犬同步标测研究中观察到了良好的准确性。此外，该技术在各种干扰和各种病理（如室性早搏和室性心动过速）下的激动序列方面保持全时间分辨率（RRE <; 0.04）。我们有希望的结果表明，在各种心律失常下的心脏激活的无创成像的优异性能，其潜在的辅助致死性室性心律失常的临床管理。
Cardiovascular disease continued to be a leading killer world widely. Each year, about 400,000 cases of sudden cardiac arrest are reported in the U.S. alone. Clinically, radio-frequency ablative procedure has become widely applied in the treatment of ventricular arrhythmia. Non-invasive approaches have been demonstrated to be able to provide important information on the arrhythmogenesis and potentially assist in the clinical practice. In this work, we develop and validate a novel temporal sparse based imaging method, Cardiac Electrical Sparse Imaging (CESI). Computer simulation and animal validation results demonstrate that the CESI approach is capable of imaging with improved accuracy and robustness by exploiting the temporal sparse property underlying cellular electrophysiology. Overall, a CC of 0.8, RE of 0.2 and LE (localization error) of 7 mm has been achieved on human realistic simulation and good accuracy has been observed in canine simultaneous mapping studies. Also, the technique maintains full temporal resolution (RRE <; 0.04) in terms of the activation sequence under various disturbances and in various pathologies such as premature ventricular complex and ventricular tachycardia. Our promising results indicate the excellent performance of noninvasive imaging of cardiac activation under various arrhythmias, and its potential for aiding clinical management of lethal ventricular arrhythmia.