A three-dimensional nonlinear active cochlear model analyzed by the WKB-numeric method

A three-dimensional nonlinear active cochlear model analyzed by the WKB-numeric method
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DOI:
10.1016/s0378-5955(02)00491-4
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发表时间:
2002-08-01
期刊:
影响因子:
2.8
通讯作者:
Steele, CR
Steele, CR
中科院分区:
医学1区
文献类型:
--
作者:
Lim, KM;Steele, CR

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提出了一种基于生理学的非线性主动耳蜗模型。该模型包括三维粘性流体效应、尺寸和材料特性沿长度变化的正交各向异性耳蜗器分区和Corti器的非线性主动前馈机制。提出了一种结合傅里叶级数展开的渐近和数值混合方法,为有源耳蜗体非线性响应的建模和仿真提供了一种快速有效的迭代方法。对栗鼠耳蜗的模拟结果与实验测量结果吻合得很好,捕捉到了基底膜反应中观察到的几个非线性特征。这些包括用刺激电平压缩响应、双音抑制以及产生谐波失真和失真乘积。(C)2002 Elsevier Science B.V.保留所有权利。
A physiologically based nonlinear active cochlear model is presented. The model includes the three-dimensional at viscous fluid effects, an orthotropic cochlear partition with dimensional and material property variation along its length, and a nonlinear active feed-forward mechanism of the organ of Corti. A hybrid asymptotic and numerical method combined with Fourier series expansions is used to provide a fast and efficient iterative procedure for modeling and simulation of the nonlinear responses in the active cochlea. The simulation results for the chinchilla cochlea compare very well with experimental measurements, capturing several nonlinear features observed in basilar membrane responses. These include compression of response with stimulus level, two-tone suppressions, and generation of harmonic distortion and distortion products. (C) 2002 Elsevier Science B.V. All rights reserved.