Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity

Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity
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SBMA 神经毒性中雄激素受体的聚谷氨酰胺扩张导致异常 E2F 激活

DOI:
10.1073/pnas.0809819106
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发表时间:
2009-03
期刊:
Proceedings of the National Academy of Sciences USA(PNAS)
影响因子:
--
通讯作者:
Shigeaki Kato
Shigeaki Kato
中科院分区:
其他
文献类型:
--
作者:
Tetsuya Tabata;Masahiko Tanabe;Hiroyuki Matsukawa;Yuko Shirode;Sally Fujiyama;Eriko Suzuki;Jinseon Lim;Saya Ito;Shun Sawatsubashi;Toshiro Aigaki;Takuya Murata;Kaoru Yamagata;Alex;er P Kouzmenko;Ken-ichi Takeyama;Takashi Ueda;Shuhei Kimura;Shigeaki Kato

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脊髓延髓肌萎缩症(SBMA)是一种由人类雄激素受体(AR)内多聚谷氨酰胺重复序列(polyQ)扩增引起的神经退行性疾病。与其他由异常polyQ扩增引起的神经退行性疾病不同,
Spinal and bulbar muscular atrophy (SBMA) is a neurodegenerative disorder caused by a polyglutamine repeat (polyQ) expansion within the human androgen receptor (AR). Unlike other neurodegenerative diseases caused by abnormal polyQ expansion, the onset of
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