Comprehensive genomic characterization of squamous cell lung cancers.
Comprehensive genomic characterization of squamous cell lung cancers.
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DOI:
10.1038/nature11404
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发表时间:
2012-09-27
期刊:
影响因子:
64.8
通讯作者:
Meyerson, Matthew
中科院分区:
文献类型:
--
作者:
Hammerman, Peter S.;Lawrence, Michael S.;Voet, Douglas;Jing, Rui;Cibulskis, Kristian;Sivachenko, Andrey;Stojanov, Petar;McKenna, Aaron;Lander, Eric S.;Gabriel, Stacey;Getz, Gad;Sougnez, Carrie;Imielinski, Marcin;Helman, Elena;Hernandez, Bryan;Pho, Nam H.;Meyerson, Matthew;Chu, Andy;Chun, Hye-Jung E.;Mungall, Andrew J.;Pleasance, Erin;Robertson, A. Gordon;Sipahimalani, Payal;Stoll, Dominik;Balasundaram, Miruna;Birol, Inanc;Butterfield, Yaron S. N.;Chuah, Eric;Coope, Robin J. N.;Corbett, Richard;Dhalla, Noreen;Guin, Ranabir;Hirst, Anhe Carrie;Hirst, Martin;Holt, Robert A.;Lee, Darlene;Li, Haiyan I.;Mayo, Michael;Moore, Richard A.;Mungall, Karen;Nip, Ka Ming;Olshen, Adam;Schein, Jacqueline E.;Slobodan, Jared R.;Tam, Angela;Thiessen, Nina;Varhol, Richard;Zeng, Thomas;Zhao, Yongjun;Jones, Steven J. M.;Marra, Marco A.;Saksena, Gordon;Cherniack, Andrew D.;Schumacher, Stephen E.;Tabak, Barbara;Carter, Scott L.;Pho, Nam H.;Nguyen, Huy;Onofrio, Robert C.;Crenshaw, Andrew;Ardlie, Kristin;Beroukhim, Rameen;Winckler, Wendy;Hammerman, Peter S.;Getz, Gad;Meyerson, Matthew;Protopopov, Alexei;Zhang, Jianhua;Hadjipanayis, Angela;Lee, Semin;Xi, Ruibin;Yang, Lixing;Ren, Xiaojia;Zhang, Hailei;Shukla, Sachet;Chen, Peng-Chieh;Haseley, Psalm;Lee, Eunjung;Chin, Lynda;Park, Peter J.;Kucherlapati, Raju;Socci, Nicholas D.;Liang, Yupu;Schultz, Nikolaus;Borsu, Laetitia;Lash, Alex E.;Viale, Agnes;Sander, Chris;Ladanyi, Marc;Auman, J. Todd;Hoadley, Katherine A.;Wilkerson, Matthew D.;Shi, Yan;Liquori, Christina;Meng, Shaowu;Li, Ling;Turman, Yidi J.;Topal, Michael D.;Tan, Donghui;Waring, Scot;Buda, Elizabeth;Walsh, Jesse;Jones, Corbin D.;Mieczkowski, Piotr A.;Singh, Darshan;Wu, Junyuan;Gulabani, Anisha;Dolina, Peter;Bodenheimer, Tom;Hoyle, Alan P.;Simons, Janae V.;Soloway, Matthew G.;Mose, Lisle E.;Jefferys, Stuart R.;Balu, Saianand;O'Connor, Brian D.;Prins, Jan F.;Liu, Jinze;Chiang, Derek Y.;Hayes, D. Neil;Perou, Charles M.;Cope, Leslie;Danilova, Ludmila;Weisenberger, Daniel J.;Maglinte, Dennis T.;Pan, Fei;Van den Berg, David J.;Triche, Timothy;Herman, James G.;Baylin, Stephen B.;Laird, Peter W.;Getz, Gad;Noble, Michael;Voet, Doug;Saksena, Gordon;Gehlenborg, Nils;DiCara, Daniel;Zhang, Jinhua;Zhang, Hailei;Wu, Chang-Jiun;Liu, Spring Yingchun;Lawrence, Michael S.;Zou, Lihua;Sivachenko, Andrey;Lin, Pei;Stojanov, Petar;Jing, Rui;Cho, Juok;Nazaire, Marc-Danie;Robinson, Jim;Thorvaldsdottir, Helga;Mesirov, Jill;Park, Peter J.;Chin, Lynda;Schultz, Nikolaus;Sinha, Rileen;Ciriello, Giovanni;Cerami, Ethan;Gross, Benjamin;Jacobsen, Anders;Gao, Jianjiong;Aksoy, B. Arman;Weinhold, Nils;Ramirez, Ricardo;Taylor, Barry S.;Antipin, Yevgeniy;Reva, Boris;Shen, Ronglai;Mo, Qianxing;Seshan, Venkatraman;Paik, Paul K.;Ladanyi, Marc;Sander, Chris;Akbani, Rehan;Zhang, Nianxiang;Broom, Bradley M.;Casasent, Tod;Unruh, Anna;Wakefield, Chris;Cason, R. Craig;Baggerly, Keith A.;Weinstein, John N.;Haussler, David;Benz, Christopher C.;Stuart, Joshua M.;Zhu, Jingchun;Szeto, Christopher;Scott, Gary K.;Yau, Christina;Ng, Sam;Goldstein, Ted;Waltman, Peter;Sokolov, Artem;Ellrott, Kyle;Collisson, Eric A.;Zerbino, Daniel;Wilks, Christopher;Ma, Singer;Craft, Brian;Wilkerson, Matthew D.;Auman, J. Todd;Hoadley, Katherine A.;Du, Ying;Cabanski, Christopher;Walter, Vonn;Singh, Darshan;Wu, Junyuan;Gulabani, Anisha;Bodenheimer, Tom;Hoyle, Alan P.;Simons, Janae V.;Soloway, Matthew G.;Mose, Lisle E.;Jefferys, Stuart R.;Balu, Saianand;Marron, J. S.;Liu, Yufeng;Wang, Kai;Liu, Jinze;Prins, Jan F.;Hayes, D. Neil;Perou, Charles M.;Creighton, Chad J.;Zhang, Yiqun;Travis, William D.;Rekhtman, Natasha;Yi, Joanne;Aubry, Marie C.;Cheney, Richard;Dacic, Sanja;Flieder, Douglas;Funkhouser, William;Illei, Peter;Myers, Jerome;Tsao, Ming-Sound;Penny, Robert;Mallery, David;Shelton, Troy;Hatfield, Martha;Morris, Scott;Yena, Peggy;Shelton, Candace;Sherman, Mark;Paulauskis, Joseph;Meyerson, Matthew;Baylin, Stephen B.;Govindan, Ramaswamy;Akbani, Rehan;Azodo, Ijeoma;Beer, David;Bose, Ron;Byers, Lauren A.;Carbone, David;Chang, Li-Wei;Chiang, Derek;Chu, Andy;Chun, Elizabeth;Collisson, Eric;Cope, Leslie;Creighton, Chad J.;Danilova, Ludmila;Ding, Li;Getz, Gad;Hammerman, Peter S.;Hayes, D. Neil;Hernandez, Bryan;Herman, James G.;Heymach, John;Ida, Cristiane;Imielinski, Marcin;Johnson, Bruce;Jurisica, Igor;Kaufman, Jacob;Kosari, Farhad;Kucherlapati, Raju;Kwiatkowski, David;Ladanyi, Marc;Lawrence, Michael S.;Maher, Christopher A.;Mungall, Andy;Ng, Sam;Pao, William;Peifer, Martin;Penny, Robert;Robertson, Gordon;Rusch, Valerie;Sander, Chris;Schultz, Nikolaus;Shen, Ronglai;Siegfried, Jill;Sinha, Rileen;Sivachenko, Andrey;Sougnez, Carrie;Stoll, Dominik;Stuart, Joshua;Thomas, Roman K.;Tomaszek, Sandra;Tsao, Ming-Sound;Travis, William D.;Vaske, Charles;Weinstein, John N.;Weisenberger, Daniel;Wheeler, David;Wigle, Dennis A.;Wilkerson, Matthew D.;Wilks, Christopher;Yang, Ping;Zhang, Jianjua John;Jensen, Mark A.;Sfeir, Robert;Kahn, Ari B.;Chu, Anna L.;Kothiyal, Prachi;Wang, Zhining;Snyder, Eric E.;Pontius, Joan;Pihl, Todd D.;Ayala, Brenda;Backus, Mark;Walton, Jessica;Baboud, Julien;Berton, Dominique L.;Nicholls, Matthew C.;Srinivasan, Deepak;Raman, Rohini;Girshik, Stanley;Kigonya, Peter A.;Alonso, Shelley;Sanbhadti, Rashmi N.;Barletta, Sean P.;Greene, John M.;Pot, David A.;Tsao, Ming-Sound;Bandarchi-Chamkhaleh, Bizhan;Boyd, Jeff;Weaver, JoEllen;Wigle, Dennis A.;Azodo, Ijeoma A.;Tomaszek, Sandra C.;Aubry, Marie Christine;Ida, Christiane M.;Yang, Ping;Kosari, Farhad;Brock, Malcolm V.;Rogers, Kristen;Rutledge, Marian;Brown, Travis;Lee, Beverly;Shin, James;Trusty, Dante;Dhir, Rajiv;Siegfried, Jill M.;Potapova, Olga;Fedosenko, Konstantin V.;Nemirovich-Danchenko, Elena;Rusch, Valerie;Zakowski, Maureen;Iacocca, Mary V.;Brown, Jennifer;Rabeno, Brenda;Czerwinski, Christine;Petrelli, Nicholas;Fan, Zhen;Todaro, Nicole;Eckman, John;Myers, Jerome;Rathmell, W. Kimryn;Thorne, Leigh B.;Huang, Mei;Boice, Lori;Hill, Ashley;Penny, Robert;Mallery, David;Curley, Erin;Shelton, Candace;Yena, Peggy;Morrison, Carl;Gaudioso, Carmelo;Bartlett, Johnm. S.;Kodeeswaran, Sugy;Zanke, Brent;Sekhon, Harman;David, Kerstin;Juhl, Hartmut;Van Le, Xuan;Kohl, Bernard;Thorp, Richard;Tien, Nguyen Viet;Van Bang, Nguyen;Sussman, Howard;Phu, Bui Duc;Hajek, Richard;PhiHung, Nguyen;Khan, Khurram Z.;Muley, Thomas;Shaw, Kenna R. Mills;Sheth, Margi;Yang, Liming;Buetow, Ken;Davidsen, Tanja;Demchok, John A.;Eley, Greg;Ferguson, Martin;Dillon, Laura A. L.;Schaefer, Carl;Guyer, Mark S.;Ozenberger, Bradley A.;Palchik, Jacqueline D.;Peterson, Jane;Sofia, Heidi J.;Thomson, Elizabeth;Meyerson, Matthew
Lung squamous cell carcinoma (lung SqCC) is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in lung SqCC have not been comprehensively characterized and no molecularly targeted agents have been developed specifically for its treatment. As part of The Cancer Genome Atlas (TCGA), we profiled 178 lung SqCCs to provide a comprehensive landscape of genomic and epigenomic alterations. Lung SqCC is characterized by complex genomic alterations, with a mean of 360 exonic mutations, 165 genomic rearrangements, and 323 segments of copy number alteration per tumor. We found statistically recurrent mutations in 18 genes in including mutation of TP53 in nearly all specimens. Previously unreported loss-of-function mutations were seen in the HLA-A class I major histocompatibility gene. Significantly altered pathways included NFE2L2/KEAP1 in 34%, squamous differentiation genes in 44%, PI3K/AKT in 47%, and CDKN2A/RB1 in 72% of tumors. We identified a potential therapeutic target in the majority of tumors, offering new avenues of investigation for lung SqCC treatment.
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影响因子:
158.5
作者:
Lynch, TJ;Bell, DW;Haber, DA
通讯作者:
Haber, DA
影响因子:
64.8
作者:
通讯作者:
--
影响因子:
30.8
作者:
通讯作者:
--
影响因子:
28.2
作者:
Hammerman PS;Sos ML;Ramos AH;Xu C;Dutt A;Zhou W;Brace LE;Woods BA;Lin W;Zhang J;Deng X;Lim SM;Heynck S;Peifer M;Simard JR;Lawrence MS;Onofrio RC;Salvesen HB;Seidel D;Zander T;Heuckmann JM;Soltermann A;Moch H;Koker M;Leenders F;Gabler F;Querings S;Ansén S;Brambilla E;Brambilla C;Lorimier P;Brustugun OT;Helland A;Petersen I;Clement JH;Groen H;Timens W;Sietsma H;Stoelben E;Wolf J;Beer DG;Tsao MS;Hanna M;Hatton C;Eck MJ;Janne PA;Johnson BE;Winckler W;Greulich H;Bass AJ;Cho J;Rauh D;Gray NS;Wong KK;Haura EB;Thomas RK;Meyerson M
通讯作者:
Meyerson M
DOI:
10.1097/jto.0b013e3181fd6fe1
发表时间:
2010-12
期刊:
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
影响因子:
--
作者:
Govindan R
通讯作者:
Govindan R