BIOLOGICAL SIGNIFICANCE OF IRON-RELATED MAGNETIC-RESONANCE-IMAGING CHANGES IN THE BRAIN
BIOLOGICAL SIGNIFICANCE OF IRON-RELATED MAGNETIC-RESONANCE-IMAGING CHANGES IN THE BRAIN
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DOI：
10.1001/archneur.1992.00530310053012
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发表时间：
1992-07-01
影响因子：
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通讯作者：
GILI, J
中科院分区：
文献类型：
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作者：
PUJOL, J;JUNQUE, C;GILI, J
铁是基本细胞新陈代谢的基本元素，在正常受试者和某些疾病患者的某些大脑区域中有规律地积累。磁共振成像可以描绘铁的沉积，提供了一个将局部铁含量与活体中人脑的功能状态联系起来的绝佳机会。我们研究了年龄与基底节T2加权像上铁相关信号丢失的关系，在大脑发育的年龄(生命的前20年)观察到苍白球信号显著减少，但在以后的几年我们没有发现这种减少。此外，在健康成年人中，受试者与受试者之间的差异与磁共振成像中铁沉积的变化有关。我们发现，信号丢失的增加与运动和特定认知任务中表现不佳有关，这表明这些图像变化可以提供关于正常受试者大脑的功能信息。
Iron, an essential element for basic cellular metabolism, regularly accumulates in certain brain areas in normal subjects and in patients with certain diseases. Magnetic resonance imaging can depict iron deposition, offering a singular opportunity to correlate regional iron content with the functional status of the human brain in vivo. We studied the relationship between age and the iron-related signal loss on T2-weighted images in basal ganglia, and observed a strongly significant signal decrease in the globus pallidus at the age of brain development (first two decades of life), but we found no such decrease in later years. Moreover, in healthy adults, subject-to-subject variability was relevant in changes due to iron deposition in magnetic resonance imaging. We found increased signal loss to be associated with poor performance on motor and specific cognitive tasks, suggesting that these image changes can provide functional information with respect to the brain in normal subjects.