Molecular hydrogen may enhance the production of testosterone hormone in male infertility through hormone signal modulation and redox balance
Molecular hydrogen may enhance the production of testosterone hormone in male infertility through hormone signal modulation and redox balance
复制标题
DOI：
10.1016/j.mehy.2018.09.001
复制
发表时间：
2018-12-01
影响因子：
4.7
通讯作者：
Lee, Kyu-Jae
中科院分区：
文献类型：
--
作者：
Begum, Rahima;Bajgai, Johny;Lee, Kyu-Jae
自氢分子(H-2)被发现以来，作为一种选择性的自由基清除剂，如活性氧(ROS)和活性氮(RNS)，大量的研究证明了H-2在治疗和预防医学中的潜在应用。此外，H-2还可以作为信号调制器调节细胞内的信号。然而，目前还不清楚与睾酮激素产生有关的细胞信号。男性生育能力取决于睾丸内的睾酮浓度，这是由睾丸中生精小管中的间质细胞产生的。尽管正常精子功能需要适量的ROS，但过高的ROS可能会减少睾酮的产生。由于氧化还原失衡，高ROS导致下丘脑至间质细胞的荷尔蒙信号失调，从而减少了睾酮激素的产生。较低水平的睾酮不能支持间质细胞进行精子发生。超氧阴离子(O-2(中心点))、羟基自由基(中心点OH)和过氧亚硝酸根(ONOO-)也可攻击DNA、脂质和蛋白质，破坏精子的结构和功能，加剧男性生育和精子发生的环境。H-2作为信号调节剂调节细胞内MAPK下游cAMP信号和钙信号，拮抗ROS信号。因此，H-2可以在调节睾酮激素产生的信号中发挥作用，以改善氧化还原失衡导致的男性生育能力。因此，我们假设分子氢可能通过细胞氧化还原平衡来促进睾酮的产生。根据这一假设，我们预计分子氢可能是治疗男性不育的有效药物。
Since the discovery of molecular hydrogen (H-2) as a selective scavenger of free radicals like reactive oxygen species (ROS) and reactive nitrogen species (RNS), numerous studies have proved the potential application of H-2 in therapeutic and preventative medicine. Moreover, H-2 can regulate the intracellular signal as a signal modulator. However, it is still unclear in cell signaling involved in testosterone hormone production.Male fertility depends on the intra-testicular testosterone concentration, which is produced by the Leydig cell in the seminiferous tubules in testes. Although moderate amounts of ROS are needed for normal sperm function, the higher amounts might decrease testosterone production. High ROS decreases testosterone hormone production by dysregulation of hormonal signal from the hypothalamus to the Leydig cell as a result of redox imbalance. Lower level of testosterone fails to support the Leydig cell for the progression of spermatogenesis. Superoxide anion (O-2(center dot-)), hydroxyl radical (center dot OH) and peroxynitrite (ONOO-) could also attack the DNA, lipid and protein, disrupting sperm structure and function and aggravating the milieu of male fertility and spermatogenesis. H-2 regulates intracellular MAPK downstream cAMP signal and Ca2+ signal as a signal modulator to antagonize ROS signaling. Thus H-2 can play a role in modulating signals involved in testosterone hormone production to improve male fertility caused by redox imbalance. We therefore hypothesize that molecular hydrogen may enhance testosterone production via cellular redox balance. By this hypothesis, we anticipate that molecular hydrogen may be an effective remedy in male infertility.