Electrocortical Dynamics in Children with a Language-Learning Impairment Before and After Audiovisual Training.
Electrocortical Dynamics in Children with a Language-Learning Impairment Before and After Audiovisual Training.
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DOI：
10.1007/s10548-015-0466-y
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发表时间：
2016-05
期刊：
影响因子：
2.7
通讯作者：
Benasich AA
中科院分区：
文献类型：
--
作者：
Heim S;Choudhury N;Benasich AA
检测和区分语音环境中细微而快速的声音变化是语言处理的基本先决条件，并且在具有语言学习障碍（LLI）的个体中经常观察到这种能力的缺陷。研究功能障碍性听觉动力学和LLI之间关联的一种方法是实施一种训练方案，在量化干预前和干预后状态的同时挖掘这种潜力。事件相关电位（ERP）对这些动态变化的大脑相关性高度敏感，因此非常适合用于检查有关听觉过程功能障碍的假设。在这项研究中，ERP测量快速的音调序列（标准和偏差的音调对）沿着与行为语言测试6- 9岁的LLI儿童（n = 21）之前和之后的视听训练。在可比的时间间隔内，对具有典型语言发育的儿童（n = 12）的非治疗组进行了两次评估。结果表明，LLI组在语言的标准化测量方面表现出相当大的进步。在ERPs方面，我们发现的证据，特别是在P2组件的水平上的LLI组的变化，迟于250毫秒后的第二个刺激的异常音对的发病。这些变化表明，训练后LLI儿童的广泛皮质中偏离标准音调序列的辨别力增强。
Detecting and discriminating subtle and rapid sound changes in the speech environment is a fundamental prerequisite of language processing, and deficits in this ability have frequently been observed in individuals with language-learning impairments (LLI). One approach to studying associations between dysfunctional auditory dynamics and LLI, is to implement a training protocol tapping into this potential while quantifying pre- and post-intervention status. Event-related potentials (ERPs) are highly sensitive to the brain correlates of these dynamic changes and are therefore ideally suited for examining hypotheses regarding dysfunctional auditory processes. In this study, ERP measurements to rapid tone sequences (standard and deviant tone pairs) along with behavioral language testing were performed in 6- to 9-year-old LLI children (n = 21) before and after audiovisual training. A non-treatment group of children with typical language development (n = 12) was also assessed twice at a comparable time interval. The results indicated that the LLI group exhibited considerable gains on standardized measures of language. In terms of ERPs, we found evidence of changes in the LLI group specifically at the level of the P2 component, later than 250 ms after the onset of the second stimulus in the deviant tone pair. These changes suggested enhanced discrimination of deviant from standard tone sequences in widespread cortices, in LLI children after training.