Modification of total body fat in spontaneously hypertensive rats and Wistar-Kyoto rats by dietary calcium and sodium.
Modification of total body fat in spontaneously hypertensive rats and Wistar-Kyoto rats by dietary calcium and sodium.
复制标题
膳食钙和钠对自发性高血压大鼠和 Wistar-Kyoto 大鼠全身脂肪的影响。
DOI：
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发表时间：
1988
影响因子：
3.2
通讯作者：
David A. McCarron
中科院分区：
文献类型：
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作者：
J. Metz;Njeri Karanja;J. Torok;David A. McCarron
研究表明，自发性高血压大鼠（SHR）消耗高钙（Ca 2+）和钠（Na+）的饮食相比，消耗低钙和钠的饮食，同时消耗类似的食物量的SHR体重轻。基于钙对脂质代谢的已知影响，确定膳食中Ca 2+和Na+的操纵是否会改变SHR的总体脂是重要的。15只SHR和17只Wistar京都大鼠（WKY）在4周龄时被随机分配到三种不同Ca 2+和Na+的饮食：2%Ca 2 +/1.0%Na+、1%Ca 2 +/0.45%Na+和0.1%Ca 2 +/0.25%Na+。在15周龄时，测定血压、体重和身体成分。在两个品系的饮食组之间观察到体重、血压和全身脂肪的显著差异。饲料中的Ca ~（2+）和Na ~（2+）诱导SHR和WKY的总体脂含量发生了有利的变化。
Studies have indicated that spontaneously hypertensive rats (SHRs) consuming diets high in calcium (Ca2+) and sodium (Na+) weigh less compared to SHRs consuming diets lower in Ca2+ and Na+ while consuming similar amounts of food. Based on calcium's known effects on lipid metabolism, it was important to determine if manipulations of dietary Ca2+ and Na+ would modify total body fat in the SHR. Fifteen SHRs and 17 Wistar Kyoto rats (WKY) were randomized at 4 weeks of age to three diets varying in Ca2+ and Na+: 2% Ca2+/1.0% Na+, 1% Ca2+/0.45% Na+, and 0.1% Ca2+/0.25% Na+. At 15 weeks of age, blood pressure, body weight, and body composition were determined. Significant differences in body weight, blood pressure, and total body fat were observed between diet groups in both strains. Dietary Ca2+ and Na+ induced favorable changes in total body fat content in both the SHR and WKY.