Effect of Cholecalciferol Supplementation During Winter Months in Patients With Hypertension: A Randomized, Placebo-Controlled Trial
Effect of Cholecalciferol Supplementation During Winter Months in Patients With Hypertension: A Randomized, Placebo-Controlled Trial
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DOI：
10.1038/ajh.2012.111
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发表时间：
2012-11-01
影响因子：
3.2
通讯作者：
Pedersen, Erling B.
中科院分区：
文献类型：
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作者：
Larsen, Thomas;Mose, Frank H.;Pedersen, Erling B.
背景：低25-羟基维生素D （25(OH)D）水平与血压（BP）呈负相关，并与高血压事件有关。生活在北纬地区的人，冬季胆骨化醇合成减少，会增加维生素D缺乏的风险。我们想验证冬季每日补充胆钙化醇能降低高血压患者血压的假设。方法：我们在一项随机、安慰剂对照、双盲研究中研究了130名居住在丹麦（北纬56度）的高血压患者每天服用75 μ g （3000 IU）胆钙化醇的效果。在10月至3月治疗20周前后测量动态血压（24小时血压）和动脉僵硬度。结果：基线p-25(OH) D为23 +/- 10 ng/ml的112例患者（平均年龄61 10岁）完成了研究。与安慰剂相比，维生素D不足（P = 0.26/0.18）的患者在24小时BR中发现3/1毫米汞柱（P = 0.26/0.18）降低不显著。
BACKGROUND Low 25-hydroxy-vitamin D (25(OH)D) levels are inversely related to blood pressure (BP) and have been associated with incident hypertension. In people living at northern latitudes diminished cholecalciferol synthesis in the winter increases the risk of vitamin D deficiency. We wanted to test the hypothesis that daily cholecalciferol supplementation in the winter lowers BP in patients with hypertension.METHODS We investigated the effect of 75 mu g (3,000 IU) cholecalciferol per day in a randomized, placebo-controlled, double-blind study in 130 hypertensive patients residing in Denmark (56 degrees N). Ambulatory BP (24-h BP) and arterial stiffness were measured before and after 20 weeks of treatment, that took place between October and March.RESULTS A total of 112 patients (mean age 61 10) with a baseline p-25(OH) D of 23 +/- 10 ng/ml completed the study. Compared with placebo, a nonsignificant 3/1 mm Hg (P = 0.26/0.18) reduction was found in 24-h BR In patients with vitamin D insufficiency (