Family history of hypertension and left ventricular mass in youth: Possible mediating parameters
Family history of hypertension and left ventricular mass in youth: Possible mediating parameters
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DOI：
10.1016/s0895-7061(00)01275-9
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发表时间：
2001-04-01
影响因子：
3.2
通讯作者：
Kapuku, GK
中科院分区：
文献类型：
--
作者：
Cook, BB;Treiber, FA;Kapuku, GK
血压正常的青年高血压(EH)阳性家族史(FH)是否与左心室重量(LVM)和血流动力学人体测量增加有关，以及先前与成人LVM增加相关的人口学参数尚不清楚，为了研究这些问题，323名健康青年(平均年龄13.6±-1.3岁)，194名EH阳性家族史(61%非裔美国人，39%白人)和129名EH阴性FH者(33%非裔美国人)。67%的白人)Evert进行了评估。分别在静息状态和四种应激源(即姿势改变、汽车驾驶模拟、电子游戏、额头冷)下测量血流动力学。超声心动图测量的左室壁厚度分别以体表面积和身高为指标(2，7)。控制年龄和种族差异(即74%的非裔美国人和47%的白人FH阳性)，FH阳性组的LVm/身高(2，7)，LVm/体表面积，较高的收缩压(SBP)和舒张压(DBP)，总外周阻力指数(TPRI)和较低的静息心脏指数(P<；0.05)。阳性FH组的SEP或DBP峰值较高，各应激源TPRI增加较多，且社会经济地位较低(均P<；0.05)。回归分析表明，EH的FH不是LVM/身高(2，7)的显著决定因素，考虑了性别(男性更大)、一般肥胖、静息心脏指数和血压(BP)以及TPRI对电子游戏和冷刺激的反应(P<；0.05)。因此，EH青年FH阳性时较大的LVM指数可能部分与他们在安静和应激时较高的BP和TPRI有关。2001年美国高血压杂志。
Whether positive family history (FH) of essential hypertension (EH) in normotensive youth is associated with increased left ventricular mass (LVM) and hemodynamic anthropometric, and demographic parameters previously associated with increased LVM in adults is unknown, To examine these issues, 323 healthy youth (mean age, 13.6 +/- 1.3 years), 194 with positive FH of EH (61% African Americans, 39% whites) and 129 with negative FH of EH (33% African Americans. 67% whites) Evert evaluated. Hemodynamics were measured at rest and during four stressors (ie, postural change, car driving simulation, video game, forehead cold). Echocardiographic-derived measures of LVM were indexed separately to body surface area and height(2,7). Controlling for age and race differences (ie, 74% of African Americans v, 47% of whites had positive FH), the positive FH group exhibited greater LVM/height(2,7), LVM/body surface area, higher systolic (SBP) and diastolic blood pressures (DBP), and total peripheral resistance index (TPRI) and lower cardiac index at rest (P < .05 for all). The positive FH group also displayed higher peak SEP or DBP and higher TPRI increases to each stressor and came from lower socioeconomic status backgrounds (P < .05 for all). Regression analyses indicated that FH of EH was not a significant determinant of LVM/height(2,7) after accounting for contributions of gender (greater in men), general adiposity, resting cardiac index and blood pressure (BP), and TPRI responsivity to video game and cold stimulation (P < .05 for all). Thus, greater LVM index; in positive FH of EH youth appears in part related to their greater BP and TPRI at rest and during stress. 2001 American Journal of Hypertension, Ltd.