RETINAL GANGLION-CELLS THAT PROJECT TO THE DORSAL LATERAL GENICULATE-NUCLEUS IN THE MACAQUE MONKEY
RETINAL GANGLION-CELLS THAT PROJECT TO THE DORSAL LATERAL GENICULATE-NUCLEUS IN THE MACAQUE MONKEY
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DOI：
10.1016/0306-4522(84)90006-x
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发表时间：
1984-01-01
期刊：
影响因子：
3.3
通讯作者：
COWEY, A
中科院分区：
文献类型：
--
作者：
PERRY, VH;OEHLER, R;COWEY, A
将辣根过氧化物酶沉积在视神经中以逆行标记并揭示所有类别神经节细胞的树突形式，或者将其注射到背外侧膝状核中以仅揭示投射到丘脑的那些类别。将结果与选择性揭示投射到中脑的神经节细胞的结果进行比较。描述了两类主要的神经节细胞：P.alpha。和P.beta。细胞。对于这两个类别，树突区域大小随着中央凹的偏心率而增加，并且在任何给定的偏心率下，这两个类别中没有重叠。细胞体大小显示出相似的平均差异，但略有重叠。对于 P.alpha 来说，沿着颞水平子午线的细胞体和树突域都比沿着鼻水平子午线更大。和P.beta。细胞，但当考虑到神经节细胞密度的鼻颞差异时，这些差异就会减少，也就是说，大小与密度密切相关。注射仅限于外侧膝状核的小细胞层，几乎全部标记为P.beta。细胞，而注射仅限于几乎完全标记为 P.alpha 的大细胞层。细胞。由于中脑注射没有标记 P.beta。细胞和少量 P.alpha。细胞，.apprx。 80%的神经节细胞是P.beta。细胞投射到小细胞外侧膝状核，并且.apprx。 10% 是 P.alpha。细胞投射到大细胞层。 P.beta 的覆盖因子（即覆盖视网膜上每个点的细胞数量）在 1.9-2.3 之间变化。细胞，P.alpha 为 2-7。细胞。将这些结果与对猫和兔子进行的类似研究的结果进行比较，发现猴子中不同类别神经节细胞的末端靶标的分离更加清晰，最大的差异是猴子中不存在从γ-和ε-样细胞向膝状体的投射。分支和支配丘脑和中脑的轴突在猴子中很少见，但在其他哺乳动物中很常见。将结果与生理学研究结果进行比较表明，P.beta。细胞对应于颜色对立细胞，而 P.alpha.细胞对应于无色宽带大细胞。
Horseradish peroxidase was deposited in the optic nerve to retrogradely label and reveal the dendritic form of all classes of ganglion cell, or it was injected into the dorsal lateral geniculate nucleus to reveal only those classes projecting to the thalamus. The results were compared with those in which the ganglion cells projecting to the midbrain were selectively revealed. Two major classes of ganglion cells are described, the P.alpha. and P.beta. cells. For both classes dendritic field size increases with eccentricity from the fovea and there is no overlap in the 2 classes at any given eccentricity. Cell body size shows a similar mean difference but with a slight overlap. Both cell bodies and dendritic fields are larger along the temporal horizontal meridian than the nasal horizontal meridian, for P.alpha. and for P.beta. cells, but these differences are reduced when naso-temporal differences in ganglion cell density are taken into account, this is, size correlates closely with density. Injections restricted to the parvocellular layers of the lateral geniculate nucleus labeled almost exclusively P.beta. cells, whereas injections confined to the magnocellular layers labeled almost exclusively P.alpha. cells. As midbrain injections label no P.beta. cells and few P.alpha. cells, .apprx. 80% of ganglion cells are P.beta. cells projecting to parvocellular lateral geniculate nucleus, and that .apprx. 10% are P.alpha. cells projecting to magnocellular layers. The coverage factor, i.e., the number of cells covering each point on the retina, varied from 1.9-2.3 for P.beta. cells and from 2-7 for P.alpha. cells. Comparing the results with those of comparable investigations on cats and rabbits shows a much clearer segregation of the terminal targets of different classes of ganglion cell in monkeys, the greatest difference being the absence in the monkey of a projection to the geniculate from gamma- and epsilon-like cells. Axons which branch and innervate both thalamus and midbrain are rare in monkeys but common in other mammals. Comparing the results with those from physiological investigations suggests that the P.beta. cells correspond to color-opponent cells, whereas P.alpha. cells correspond to achromatic broad-band magnocellular cells.