Non-steroidal anti-inflammatory drug-induced renal failure: a brief review of the role of cyclo-oxygenase isoforms.
Non-steroidal anti-inflammatory drug-induced renal failure: a brief review of the role of cyclo-oxygenase isoforms.
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非甾体抗炎药引起的肾衰竭：环加氧酶亚型作用的简要回顾。
DOI：
10.1097/00041552-199801000-00013
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发表时间：
1998
影响因子：
3.2
通讯作者：
P. Needleman
中科院分区：
文献类型：
--
作者：
Venturini Cm;P. Isakson;P. Needleman
非类固醇消炎药是治疗类风湿性关节炎和骨性关节炎的有效药物。然而，使用非类固醇抗炎药治疗的一个不良反应是急性肾功能衰竭，特别是在有效容量耗竭状态的患者亚组中。这种副作用在一般治疗人群中的频率尚不清楚，但每年可能不到1%。非类固醇抗炎药通过抑制前列腺素的合成发挥作用，前列腺素是肾功能的重要介质。在容量耗竭状态下，前列腺素可以对抗与肾素-血管紧张素系统激活相关的血管收缩。环氧合酶是前列腺素合成的限速酶。环氧合酶以两种形式存在：结构性形式(环氧合酶-1)和诱导型形式(环氧合酶-2)，与炎症有关。非类固醇抗炎药是两种形式的环氧合酶的非特异性抑制剂。关于环氧合酶-2在控制肾功能中的作用的新数据正在出现。在正常大鼠和狗的肾脏中，环氧合酶-2在致密斑区有少量表达，但在动物体积耗尽时表达上调。本综述探讨了在容量耗竭状态下，环氧合酶-2在维持正常肾功能中的可能作用。
Non-steroidal anti-inflammatory drugs are efficacious treatments for rheumatoid arthritis and osteoarthritis. However, an adverse effect of treatment with non-steroidal anti-inflammatory drugs is acute renal failure, particularly in a subset of patients that are in a state of effective volume depletion. The frequency of this side-effect in the general treated population is not known, but is probably less than 1% per year. Non-steroidal anti-inflammatory drugs act by inhibiting the synthesis of prostaglandins, which are important mediators of renal function. In the volume-depleted state prostaglandins may counter the vasoconstriction associated with the activation of the renin-angiotensin system. Cyclooxygenase is the rate-limiting enzyme involved in the synthesis of prostaglandins. Cyclooxygenase exists in two forms: a constitutive form (cyclooxygenase-1) and an inducible form (cyclooxygenase-2), which is associated with inflammation. Non-steroidal anti-inflammatory drugs are non-specific inhibitors of both forms of cyclooxygenase. New data are emerging regarding the role of cyclooxygenase-2 in the control of renal function. In normal rat and dog kidney, cyclooxygenase-2 is sparsely expressed in the macula densa, but expression is upregulated when animals are volume depleted. This review explores the possible role of cyclooxygenase-2 in the maintenance of normal renal function in volume depleted states.
影响因子：
15.9
作者：
HARRIS, RC;MCKANNA, JA;BREYER, MD
通讯作者：
BREYER, MD