Functional MRI detection of activation in the primary gustatory cortices in humans
Functional MRI detection of activation in the primary gustatory cortices in humans
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DOI：
10.1093/chemse/bji052
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发表时间：
2005-09-01
期刊：
影响因子：
3.5
通讯作者：
Saito, S
中科院分区：
文献类型：
--
作者：
Ogawa, H;Wakita, M;Saito, S
最近的脑磁图（MEG）研究发现，在最短的潜伏期内，顶盖（Pop）和中央沟（CS）之间的过渡区（G区）被味觉刺激激活，提示初级味觉区位于这两个区域。然而，使用其他非侵入性脑成像方法的研究，如正电子发射断层扫描或功能性磁共振成像（fMRI），并将促味剂手动应用于口中，无法证实这一点。本研究用计算机控制的刺激器用1 M NaCl重复刺激舌尖来检查皮层激活，并使用功能磁共振成像来检测。在个体大脑中，通过多重比较检测到激活（错误发现率）在整个大脑纠正11例受试者中有8例在G区和额盖（Fop）两个部位，7例在罗兰岛盖（Rop）两个部位（P < 0.05）。在CS的腹侧端也发现激活（n = 3）。采用随机效应模型进行的组分析（使用感兴趣区域的家族误差进行多重比较，P < 0.02）显示，在两个半球的G区以及左侧CS的Fop、Rop和腹侧端都有激活。目前的研究表明，没有激活的大脑外表面的回，除了ROP。考虑到MEG的研究结果，目前的研究结果强烈表明，主要的味觉区是存在于流行音乐和流行音乐之间的过渡和Rop，包括灰质内的腹侧部分的CS。
Magnetoencephalography (MEG) has recently revealed that the transitions between the parietal operculum (Pop) and the insula (area G) and the ventral end of the central sulcus (cs) were activated with the shortest latency by instrumental gustatory stimulation, which suggests that the location of the primary gustatory area is in these two regions. However, studies using other noninvasive brain-imaging methods such as positron-emission tomography or functional magnetic resonance imaging (fMRI) with manual application of tastants into the mouth have been unable to confirm this. The present study examined cortical activation by repetitive stimulation of the tongue tip with 1 M NaCl with a computer-controlled stimulator and used fMRI to detect it. In individual brains, activations were detected with multiple comparisons (false discovery rate) across the whole brain corrected (threshold at P < 0.05) at both area G and frontal operculum (Fop) in 8 of 11 subjects and at the rolandic operculum (Rop) in 7 subjects. Activations were also found at the ventral end of the cs (n = 3). Group analysis with random-effect models (multiple comparison using familywise error in regions of interest, P < 0.02) revealed activation at area G in both hemispheres and in the Fop, Rop, and ventral end of the cs on the left side. The present study revealed no activation on the gyrus of the external cerebral surface except for the Rop. Taking MEG findings into consideration, the present findings strongly indicate that the primary gustatory area is present at both the transition between the Pop and insula and the Rop including the gray matter within a ventral part of the cs.