Drugs that target aging: how do we discover them?
Drugs that target aging: how do we discover them?
复制标题
抗衰老药物：我们如何发现它们？
DOI：
10.1080/17460441.2019.1597049
复制
发表时间：
2019
影响因子：
6.3
通讯作者：
Lithgow,GJ
中科院分区：
文献类型：
--
作者：
Myers,A;Lithgow,GJ
简介：衰老生物学的重点是阐明随着时间的推移导致细胞损伤积累的生化和遗传途径。随着第一批基于衰老生物学的药物干预措施通过临床试验，30年的研究开始取得成果。衰老的进化理论表明，被认为赋予年轻生物体健康的自然选择的特征可能在以后的生活中是有害的。衰老生物学的三个主要关注领域是寿命、健康寿命和恢复活力。所涵盖的领域：衰老研究已经产生了几种有效的药理学干预措施，目前正在临床试验中。在此，作者考虑了两个代表性的案例研究：1）雷帕霉素类似物及其对mTORC 1通路的影响，以及2）靶向和杀死衰老细胞的小分子。作者还提供了他们对衰老靶向药物发现的专家当前和未来观点。专家意见：衰老相关的治疗干预将继续以加速的步伐出现，无论是从衰老生物学研究，还是从衰老相关慢性病的协调生物医学研究。
Introduction: Biology of aging is focused on elucidating the biochemical and genetic pathways that contribute to cellular damage accumulation over time. Thirty years of research are beginning to bear fruit as the first pharmacological interventions based on biology of aging go through clinical trials. Evolutionary theories of aging suggest that naturally selected traits believed to impart fitness in young organisms may be damaging in later life. Three major areas of focus in biology of aging are lifespan, healthspan, and rejuvenation.Areas covered: Aging research has produced several validated pharmacological interventions currently in clinical trials. Herein, the authors consider two representative case studies: 1) rapamycin analogs and their effect on the mTORC1 pathway, and 2) small molecules that target and kill senescent cells. The authors also provide their expert current and future perspectives on aging targeting drug discovery.Expert opinion: Aging-related therapeutic interventions will continue to emerge at an accelerating pace, both from research in biology of aging, as well as from coordinated biomedical research in aging-related chronic conditions.