BODY-WEIGHT AND LONGEVITY - A REASSESSMENT
BODY-WEIGHT AND LONGEVITY - A REASSESSMENT
复制标题
DOI：
10.1001/jama.257.3.353
复制
发表时间：
1987-01-16
影响因子：
120.7
通讯作者：
WILLETT, WC
中科院分区：
文献类型：
--
作者：
MANSON, JE;STAMPFER, MJ;WILLETT, WC
关于体重和寿命之间的联系，已有相互矛盾的结果报道。体重与全因死亡率的关系曲线的形状有不同的描述，有线性的、J型的，甚至是U型的。为了评估最佳体重建议的证据的有效性，我们检查了关于这一主题的25项主要前瞻性研究。每项研究至少有三个主要偏差之一：(1)未能控制吸烟，(2)不适当控制肥胖的生物影响，如高血压和高血糖，以及(3)未能控制因亚临床疾病而导致的体重减轻。这些偏见的存在导致了对肥胖对过早死亡的影响的系统性低估。尽管这些偏见排除了现有数据对最佳体重的有效评估，但现有证据表明，最低死亡率发生在相对权重至少比美国平均水平低10%的情况下。
Conflicting results have been reported concerning the association between body weight and longevity. The shape of the curve relating weight to all-cause mortality has been variously described as linear, J-shaped, and even U-shaped. To assess the validity of the evidence for optimal weight recommendations, we examined the 25 major prospective studies on the subject. Each study had at least one of three major biases: (1) failure to control for cigarette smoking, (2) inappropriate control of biologic effects of obesity, such as hypertension and hyperglycemia, and (3) failure to control for weight loss due to subclinical disease. The presence of these biases leads to a systematic underestimate of the impact of obesity on premature mortality. Although these biases preclude a valid assessment of optimal weight from existing data, available evidence suggests that minimum mortality occurs at relative weights at least 10% below the US average.