An Overview of Organ-on-a-Chip Models for Recapitulating Human Pulmonary Vascular Diseases.
An Overview of Organ-on-a-Chip Models for Recapitulating Human Pulmonary Vascular Diseases.
复制标题
用于重现人类肺血管疾病的器官芯片模型概述。
DOI：
10.1007/978-3-031-26625-6_13
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发表时间：
2023
影响因子：
--
通讯作者：
Ahsan,Fakhrul
中科院分区：
文献类型：
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作者：
Nguyen,Trieu;Ahsan,Fakhrul
传统上，动物模型已被用于再现人类生理学和研究影响人类的许多疾病的病理基础。事实上，几个世纪以来，动物模型帮助我们加深了对人类药物治疗的生物学和病理学的理解。然而，随着基因组学和药物基因组学的出现，我们现在知道，传统的模型不能准确地捕捉人类的病理条件和生物过程，尽管人类与许多动物有许多共同的生理和解剖特征[1-3]。物种间的差异引起了人们对研究人类状况的动物模型的有效性和适用性的关注。在过去的十年中，微制造和生物材料的发展和进步刺激了微工程组织和器官模型（器官芯片，OoC）的发展，作为动物和细胞模型的替代品[4]。这种最先进的技术已被用于模拟人类生理学，以研究疾病病理基础中涉及的大量细胞和生物分子过程（图13.1）[4]。由于其巨大的潜力，基于面向对象的模型已被列为2016年世界经济论坛十大新兴技术之一[2]。
Traditionally, animal models have been used for recapitulating human physiology and for studying the pathological basis of many diseases affecting humankind. Indeed, over the centuries, animal models helped advance our understanding of the biology and pathology of drug therapy for humans. However, with the advent of genomics and pharmacogenomics, we now know that conventional models cannot accurately capture the pathological conditions and biological processes in humans, although humans share many physiological and anatomical features with many animals [1–3]. Species to species variation have raised concerns about the validity and suitability of animal models for studying human conditions. Over the past decade, the development and advances in microfabrication and biomaterials have spurred the growth in micro-engineered tissue and organ models (organs-on-a-chip, OoC) as alternatives to animal and cellular models [4]. This state-of-the-art technology has been used to emulate human physiology for investigating multitudes of cellular and biomolecular processes implicated in the pathological basis of disease (Fig. 13.1) [4]. Because of their tremendous potential, OoC-based models have been listed as one of the top 10 emerging technologies in the 2016 World Economic Forum [2].