Ethyl linolenate is elevated in meconium of very-low-birth-weight neonates exposed to alcohol in utero.
Ethyl linolenate is elevated in meconium of very-low-birth-weight neonates exposed to alcohol in utero.
复制标题
在子宫内接触酒精的极低出生体重新生儿的胎便中亚麻酸乙酯含量升高。
DOI：
10.1038/pr.2016.237
复制
发表时间：
2017
影响因子：
3.6
通讯作者：
Gauthier,TheresaW
中科院分区：
文献类型：
--
作者：
Gross,TeresaS;Harris,Frank;Brown,LouAnnS;Gauthier,TheresaW
背景：由于无法识别母亲的酒精暴露，因此很难对极低出生体重儿（VLBW）进行宫内酒精暴露的健康影响研究。酒精暴露的足月新生儿胎粪中脂肪酸乙酯（FAEEs）升高。我们假设，胎粪FAEEs将同样升高酒精暴露VLBW早产新生儿。方法：在一项回顾性队列研究64 VLBW新生儿，新生儿被分为非暴露，任何暴露，或每周暴露组的基础上，在深入的结构化的母亲采访。胎粪FAEE浓度通过气相色谱质谱定量。结果：酒精暴露在妊娠期1（任何暴露）发生在约30%的怀孕，而11%的受试者报告饮酒≥ 1饮料/周（每周暴露）。与未暴露VLBW组相比，任何暴露组（P= 0.01）和每周暴露组（P= 0.005）的胎粪亚麻酸乙酯较高。第1孕期饮酒量与胎粪亚麻酸乙酯浓度呈显著正相关（P= 0.005）。校正后的受试者工作特征（ROC）曲线评价亚麻酸乙酯对酒精暴露的VLBW新生儿的曲线下面积为88%，敏感性为86-89%，特异性为83- 88%。
Background:The health implications of in utero alcohol exposure have been difficult to study in very-low-birth-weight newborns (VLBW) because of an inability to identify maternal alcohol exposure. Fatty acid ethyl esters (FAEEs) are elevated in meconium of alcohol-exposed term newborns. We hypothesized that meconium FAEEs would be similarly elevated in alcohol-exposed VLBW premature newborns.Methods:In a retrospective cohort study of 64 VLBW neonates, newborns were classified into Non-Exposed, Any Exposure, or Weekly Exposure groups based on an in-depth structured maternal interview. Meconium FAEE concentrations were quantified via gas chromatography mass spectrometry.Results:Alcohol exposure during Trimester 1 (Any Exposure) occurred in~ 30% of the pregnancies, while 11% of the subjects reported drinking≥ 1 drink/week (Weekly Exposure). Meconium ethyl linolenate was higher in Any Exposure (P= 0.01) and Weekly Exposure groups (P= 0.005) compared to the Non-Exposed VLBW group. There was a significant positive correlation between Trimester 1 drinking amounts and the concentration of meconium ethyl linolenate (P= 0.005). Adjusted receiver operating characteristic (ROC) curves evaluating ethyl linolenate to identify alcohol-exposed VLBW newborns generated areas under the curve of 88% with sensitivities of 86–89% and specificities of 83–88%.Conclusion:Despite prematurity, meconium FAEEs hold promise to identify the alcohol-exposed VLBW newborn.Similar content being viewed by others