Glycyrrhizin, an active component of licorice roots, reduces morbidity and mortality of mice infected with lethal doses of influenza virus
Glycyrrhizin, an active component of licorice roots, reduces morbidity and mortality of mice infected with lethal doses of influenza virus
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DOI：
10.1128/aac.41.3.551
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发表时间：
1997-03-01
影响因子：
4.9
通讯作者：
Suzuki, F
中科院分区：
文献类型：
--
作者：
Utsunomiya, T;Kobayashi, M;Suzuki, F
本文观察了甘草有效成分甘草苷（GR）对甲型流感病毒A（2）（H2 N2）感染小鼠的抗病毒作用。所有小鼠在21天的实验期内存活，在该期结束时，用盐水处理的对照小鼠的平均存活时间（天）为10.5天，并且没有存活者。GR对流感病毒A在体外的存活和复制无影响。将GR处理的小鼠脾T细胞过继转移给流感病毒暴露的小鼠，100%的受体存活，与接种来自GR处理小鼠的初始T细胞或脾B细胞和巨噬细胞的受体小鼠的0%存活率相比，另外，当将GR与抗γ干扰素组合施用于感染小鼠时，未证实GR对小鼠流感病毒感染的抗病毒活性这些结果表明，GR可以通过刺激T细胞产生IFN-γ来保护暴露于致死量流感病毒的小鼠，因为T细胞已被证明是用该化合物刺激的IFN-γ的生产细胞。
The antiviral effect of glycyrrhizin (GR), an active component of licorice roots, was investigated in mice infected with influenza virus A(2) (H2N2), When mice that had been exposed to 10 50% lethal doses of the virus were treated intraperitoneally with 10 mg of GR per kg of body weight 1 day before infection and 1 and 4 days postinfection, all of the mice survived over the 21-day experimental period, At the end of this period, the mean survival time (in days) for control mice treated with saline was 10.5 days, and there were no survivors, The grade of pulmonary consolidations and the virus titers in the lung tissues of infected mice treated,vith GR were significantly lower than those in the lung tissues of infected mice treated with saline, GR did not show any effects on the viability or replication of influenza virus A, in vitro, When splenic T cells from GR-treated mice were adoptively transferred to mice exposed to influenza virus, 100% of the recipients survived, compared to 0% survival for recipient mice inoculated with naive T cells or splenic B cells and macrophages from GR-treated mice, In addition, the antiviral activities of GR on influenza virus infection in mice were not demonstrated when it was administered to infected mice in combination with anti-gamma interferon (anti-IFN-gamma) monoclonal antibody, These results suggest that GR may protect mice exposed to a lethal amount of influenza virus through the stimulation of IFN-gamma production by T cells, because T cells have been shown to be producer cells of IFN-gamma stimulated with the compound.