Catalytic asymmetric Henry reaction
Catalytic asymmetric Henry reaction
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DOI：
10.1016/j.tetasy.2006.12.005
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发表时间：
2006-12-27
影响因子：
--
通讯作者：
Barua, Nabin C.
中科院分区：
文献类型：
--
作者：
Boruwa, Joshodeep;Gogoi, Naminita;Barua, Nabin C.
经典的亨利反应，即硝基烷烃与羰基化合物在碱存在下的偶联反应，是有机化学中一个重要的C-C键形成反应，生成β-硝基醇，后者是有机合成中有用的取代基。然而，一个不对称的版本的反应，这是最近开发的，给出了一个新的层面的经典亨利反应，从而控制两个新产生的碳中心的立体化学已成为可能。本文综述了用于此目的的各种催化方法。(c)2007爱思唯尔有限公司保留所有权利。
The classical Henry reaction, the coupling of a nitroalkane with a carbonyl compound in the presence of a base, is an important C-C bond forming reaction in organic chemistry giving beta-nitroalcohols, which are useful synthons in organic synthesis. However, an asymmetric version of the reaction, that has been developed recently, gives a new dimension to the classical Henry reaction whereby the control of stereochemistry of two newly generated carbon centres has become possible. In this review, the various catalytic methods for this purpose are discussed. (c) 2007 Elsevier Ltd. All rights reserved.