Oxidative stress profiling Part I. Its potential importance in the optimization of human health
Oxidative stress profiling Part I. Its potential importance in the optimization of human health
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DOI：
10.1196/annals.1323.027
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Cutler, RG
中科院分区：
文献类型：
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作者：
Cutler, RG
不断积累的科学证据支持组织和细胞成分的氧化损伤作为许多不同人类疾病和衰老过程中的主要或次要致病因素的普遍重要性。我们的目标是开发灵敏可靠的方法来测量个体的氧化损伤和防御/修复状态，这些方法可以很容易地被医生用来确定患者在氧化损伤方面是否存在直接或长期的健康风险增加。我们还试图确定如何最好地降低这种风险，处方治疗是否有效，以及如何最好地调整以优化收益。我们已经发现，将氧化损伤概况与防御/修复概况相结合可以产生最可靠的信息集，以满足这些目标。通过证明数百人的群体的氧化应激与抗氧化状态的预期负相关性来指示成功。我们还发现支持氧化应激状态是在严格的监管控制下，大多数人在广泛的生活方式变量，包括饮食和运动。事实上，在分析的个体中，只有大约10%的人似乎具有异常高的氧化应激水平。只有这些具有高于正常水平的氧化应激的个体是抗氧化剂补充剂的最佳反应者，以将其氧化应激状态降低至正常水平。我们讨论了这些结果对人类应用的影响，并回顾了目前的临床研究是如何进行的，以评估抗氧化剂补充剂在降低特定年龄依赖性疾病发病率方面的益处。
Steadily accumulating scientific evidence supports the general importance of oxidative damage of tissue and cellular components as a primary or secondary causative factor in many different human diseases and aging processes. Our goal has been to develop sensitive and reliable means to measure the oxidative damage and defense/repair status of an individual that could be easily used by a physician to determine whether there is an immediate or long-term increased health risk to their patients with regard to oxidative damage. We also sought to try to determine how this risk can best be reduced, and whether the prescribed therapy is working and how it might be best adjusted to optimize benefits. We have found that combining both an oxidative damage profile with a defense/repair profile produces the most reliable set of information to meet these objectives. Success is indicated by demonstrating the expected inverse correlation of oxidative stress vs. antioxidant status of a population of several hundred individuals. We also find support that oxidative stress status is under tight regulatory control for most individuals over a wide range of lifestyle variables including diet and exercise. Indeed only about 10% of the individuals analyzed appear to have unusually high oxidative stress levels. Only these individuals having the higher than normal levels of oxidative stress are the best responders to antioxidant supplements to lower their oxidative stress status to normal levels. We discuss the implications of these results for human application and review how current clinical studies are carried out to evaluate the benefits of antioxidant supplements in reducing the incidence of specific age-dependent disease.