Effects of age and sex on the hematology and blood chemistry of Tibetan macaques (Macaca thibetana).
Effects of age and sex on the hematology and blood chemistry of Tibetan macaques (Macaca thibetana).
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发表时间：
2014
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通讯作者：
Di Wu;Y. Yi;Fei Sun;Liang Zhou;Feng Yang;Hongxing Wang;Guodong Zhang;Yu Zhang;F. Yue
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作者：
Di Wu;Y. Yi;Fei Sun;Liang Zhou;Feng Yang;Hongxing Wang;Guodong Zhang;Yu Zhang;F. Yue
藏猕猴（Macaca thibetana），又名中国短尾猴，是一种受威胁的灵长类动物。尽管藏猕猴属于旧世界猕猴属，但该物种与年龄和性别相关的生理数据有限。我们使用 69 只表面健康的雄性和雌性藏族猕猴来探讨年龄和性别对生理参数的影响。分析了体测测量、生物化学和血液学参数。体重、BMI、红细胞计数、Hgb、Hct、中性粒细胞、嗜酸性粒细胞计数、ALT、AST、ALP、GGT、肌酸激酶（肌肉和脑亚型）、LDH、α-淀粉酶、肌酐、载脂蛋白 A1、总蛋白、白蛋白、胆固醇、HDL 和钾存在显着的年龄相关差异。体重、BMI、ALT、总胆红素和间接胆红素之间存在显着的性别差异。年龄和性别之间的相互作用导致体重、BMI、淋巴细胞和嗜酸性粒细胞计数值存在统计学上的显着差异。这些生理数据将为兽医和研究人员提供重要的年龄和性别参考范围，以评估藏猕猴的实验结果。
Tibetan macaques (Macaca thibetana), also known as Chinese stump-tailed macaques, are a threatened primate species. Although Tibetan macaques are Old World monkeys in the genus of Macaca, limited age- and sex-related physiologic data are available for this particular species. We used 69 apparently healthy Tibetan male and female macaques to explore the effect of age and sex on physiologic parameters. Somatometric measurements, biochemistry, and hematologic parameters were analyzed. Significant age-related differences were found for weight, BMI, RBC count, Hgb, Hct, neutrophils, eosinophil count, ALT, AST, ALP, GGT, creatine kinase (muscle and brain subtypes), LDH, α-amylase, creatinine, apolipoprotein A1, total protein, albumin, cholesterol, HDL, and potassium. Significant differences by sex were noted for weight, BMI, ALT, total bilirubin, and indirect bilirubin. An interaction between age and sex accounted for statistically significant differences in the values for weight, BMI, and lymphocyte and eosinophil counts. These physiologic data will provide veterinarians and researchers with important age- and sex-specific reference ranges for evaluating experimental results from Tibetan macaques.