The role of peroxisome proliferator-activated receptors in pulmonary vascular disease.
The role of peroxisome proliferator-activated receptors in pulmonary vascular disease.
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DOI：
10.1155/2007/18797
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发表时间：
2007
期刊：
影响因子：
2.9
通讯作者：
Hart CM
中科院分区：
文献类型：
--
作者：
Nisbet RE;Sutliff RL;Hart CM
过氧化物酶体增殖物激活受体（PPARs）是属于核激素受体超家族的配体激活的转录因子，其调节从脂肪生成到炎症的多种生理过程。最近的证据已经确定了PPARs在全身和肺血管疾病和功能中的潜在作用。肺动脉高压是肺血管疾病最常见的表现，现有的治疗策略受到对潜在疾病发病机制的不完全理解和缺乏疗效的限制，这表明迫切需要新的方法来治疗这种疾病。肺内皮源性介质的紊乱和内皮功能障碍在肺动脉高压的发病机制中起着关键作用。因此，以下综述将集中于与肺血管功能障碍有关的选定介质以及PPARs，特别是PPARγ参与其调节的证据，并可能为肺动脉高压的治疗提供潜在的新靶点。
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily that regulate diverse physiological processes ranging from lipogenesis to inflammation. Recent evidence has established potential roles of PPARs in both systemic and pulmonary vascular disease and function. Existing treatment strategies for pulmonary hypertension, the most common manifestation of pulmonary vascular disease, are limited by an incomplete understanding of the underlying disease pathogenesis and lack of efficacy indicating an urgent need for new approaches to treat this disorder. Derangements in pulmonary endothelial-derived mediators and endothelial dysfunction have been shown to play a pivotal role in pulmonary hypertension pathogenesis. Therefore, the following review will focus on selected mediators implicated in pulmonary vascular dysfunction and evidence that PPARs, in particular PPARγ, participate in their regulation and may provide a potential novel therapeutic target for the treatment of pulmonary hypertension.
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DOI：
10.1161/01.atv.0000143855.85343.0e
发表时间：
2004-11-01
影响因子：
8.7
作者：
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DOI：
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