Inhibitory and facilitatory connections from dorsolateral prefrontal to primary motor cortex in healthy humans at rest-An rTMS study
Inhibitory and facilitatory connections from dorsolateral prefrontal to primary motor cortex in healthy humans at rest-An rTMS study
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DOI：
10.1016/j.neulet.2018.09.032
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发表时间：
2018-11-20
影响因子：
2.5
通讯作者：
Tan, Xiaoying
中科院分区：
文献类型：
--
作者：
Cao, Na;Pi, Yanling;Tan, Xiaoying
背景：人类的运动系统由额叶的几个部分组成。背外侧前额叶皮层（DLPFC）到初级运动皮层（M1）的投射的生理功能仍然是难以捉摸的。在这里，我们介绍了theta爆发刺激（TBS）为基础的协议，以目标的抑制和易化连接在DLPFC-M1 network.Methods：间歇性和连续TBS 600脉冲（iTBS 600/cTBS 600）施加到左侧DLPFC。经颅磁刺激同侧M1，测定静息运动阈值（RMT）、运动诱发电位（MEP）和短间期皮质内抑制（SICI）。相反，DLPFC的cTBS 600增加M1的MEP振幅。iTBS 600后MEP振幅的峰值降低与cTBS 600后MEP振幅的峰值增加呈负相关。有没有显着的影响，在对照组与sham stimulation.Discussion：这些结果提供了深入了解的调节抑制和便利的平衡，从当地DLPFC到M1。一个大脑区域中的TBS调制将诱导其他远程皮层区域内的相互作用。我们的研究结果使我们能够更好地理解认知资源是如何分配的，以实现最佳控制的运动输出。
Background: The human motor system consists of several divisions in the frontal lobes. The physiological function of projections from the dorsolateral prefrontal cortex (DLPFC) to the primary motor cortex (M1) remains elusive. Here, we introduce theta burst stimulation (TBS)-based protocols to target inhibitory and facilitatory connections in the DLPFC-M1 network.Methods: Intermittent and continuous TBS with 600 pulses (iTBS600/cTBS600) were applied to the left DLPFC. Resting motor threshold (RMT), motor-evoked potential (MEP), and short-interval intracortical inhibition (SICI) were measured with transcranial magnetic stimulation to the ipsilateral M1.Results: iTBS600 to the DLPFC decreased MEP amplitude in M1. Conversely, cTBS600 to the DLPFC increased MEP amplitude in M1. The peak decrease in MEP amplitude after iTBS600 was negatively correlated with the peak increase in MEP amplitude after cTBS600. There were no significant effects in the control group with the sham stimulation.Discussion: These results provide insight into the regulation of inhibitory and facilitatory balance from the local DLPFC to M1. TBS modulation in one brain region will induce interactions within other remote cortical areas. Our results enable better understanding of how cognitive resources are allocated to achieve optimal control of motor output.