Curcumin decreases oxidative stress in mitochondria isolated from liver and kidneys of high-fat diet-induced obese mice
Curcumin decreases oxidative stress in mitochondria isolated from liver and kidneys of high-fat diet-induced obese mice
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DOI：
10.1080/10286020.2013.802687
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发表时间：
2013-08-01
影响因子：
1.7
通讯作者：
Ramirez-Emiliano, Joel
中科院分区：
文献类型：
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作者：
Martinez-Morua, Antonia;Soto-Urquieta, Maria G.;Ramirez-Emiliano, Joel
氧化应激在肥胖和糖尿病相关的线粒体功能障碍中起着关键作用。线粒体功能障碍的特征是氧化损伤增加，一氧化氮（NO）合成增加，腺苷-5'-三磷酸（ATP）生成/氧消耗比例降低。姜黄素是一种潜在的抗氧化剂和抗炎剂。在这项研究中，我们的目的是确定姜黄素治疗对高脂肪饮食（HFD）诱导的肥胖小鼠（OM）氧化应激和线粒体功能障碍的影响。这些结果表明，与未处理的OM （UOM）相比，姜黄素处理增加了hfd诱导OM分离的肝脏线粒体的耗氧量，并显著降低了脂质和蛋白质氧化水平。在肾脏线粒体中，姜黄素处理显著增加了hfd诱导的OM的耗氧量，降低了脂质和蛋白质过氧化水平。姜黄素治疗对体重增加没有任何影响，对线粒体NO合成也没有任何影响。这些发现表明，肥胖诱导氧化应激和线粒体功能障碍，而姜黄素可能对肥胖诱导的氧化应激和线粒体功能障碍具有保护作用。
Oxidative stress plays a key role in obesity and diabetes-related mitochondrial dysfunction. Mitochondrial dysfunction is characterized by increased oxidative damage, nitric oxide (NO) synthesis, and a reduced ratio of adenosine-5'-triphosphate (ATP) production/oxygen consumption. Curcumin represents a potential antioxidant and anti-inflammatory agent. In this study, our objective was to determine the effect of curcumin treatment on oxidative stress and mitochondrial dysfunction in high-fat diet (HFD)-induced obese mice (OM). These results suggest that curcumin treatment increased oxygen consumption and significantly decreased lipid and protein oxidation levels in liver mitochondria isolated from HFD-induced OM compared with those in the untreated OM (UOM). In kidney mitochondria, curcumin treatment significantly increased oxygen consumption and decreased lipid and protein peroxidation levels in HFD-induced OM when compared with those in UOM. Curcumin treatment neither has any effect on body weight gain nor have any effects on mitochondrial NO synthesis. These findings suggest that obesity induces oxidative stress and mitochondrial dysfunction, whereas curcumin may have a protective role against obesity-induced oxidative stress and mitochondrial dysfunction.