Kindlin-2 expression in adult tissues correlates with their embryonic origins
Kindlin-2 expression in adult tissues correlates with their embryonic origins
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Kindlin-2 在成人组织中的表达与其胚胎起源相关
DOI：
10.1007/s11427-014-4676-4
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发表时间：
2014-07-01
影响因子：
9.1
通讯作者：
Zhang HongQuan
中科院分区：
文献类型：
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作者：
Zhan Jun;Yang Mei;Zhang HongQuan
Kindlin-2在维持体内平衡和人类疾病中发挥作用。本研究调查了组织中Kindlin-2表达与这些组织起源的相应胚层之间的相互关系。用免疫组化方法检测Kindlin-2在正常成人器官和人癌组织中的表达。对Oncomine数据集中成人器官中Kindlin-2 mRNA水平的分析显示，Kindlin-2在中胚层来源的器官中高度表达。而Kindlin-2在内/外胚层来源的器官中呈阴性或弱表达。有趣的是，在多种人类癌症中观察到Kindlin-2的异常表达。与其在人类中的表达谱一致，Kindlin-2在小鼠胚胎中的中胚层来源的器官中也高度表达，除了Kindlin-2在胚胎发育期间高度移动的的外胚层来源的脊髓和神经节组织中的强表达。重要的是，我们证明了Kindlin-2在成人器官中的表达水平与其胚胎真皮起源相关，并且组织中Kindlin-2的失调与肿瘤进展相关。这一发现将有助于我们理解Kindlin-2在调节肿瘤进展和胚胎发育中的双重作用。
Kindlin-2 functions in the maintenance of homeostasis and in human diseases. This study investigated the interrelationship between Kindlin-2 expression in tissues and the corresponding germ layers from which these tissues originated. Kindlin-2 expression was examined in normal adult human organs and human cancer tissues by immunohistochemical analyses. Analysis of Kindlin-2 mRNA levels in adult human organs in the Oncomine dataset revealed Kindlin-2 is highly expressed in mesoderm-derived organs. However, Kindlin-2 was negative or weakly expressed in endoderm/ectoderm-derived organs. Interestingly, the abnormal expression of Kindlin-2 was observed in a variety of human cancers. In agreement with its expression profile in humans, Kindlin-2 was also highly expressed in mesoderm-derived organs in mouse embryos with the exception of strong Kindlin-2 expression in ectoderm-derived spinal cord and ganglia, tissues that are highly mobile during embryonic development. Importantly, we demonstrated the expression level of Kindlin-2 in adult organs correlated with their embryonic dermal origins and deregulation of Kindlin-2 in tissues is associated with tumor progression. This finding will help us understand the dual role of Kindlin-2 in the regulation of tumor progression and embryonic development.