Lipid rafts generate digital-like signal transduction in cell plasma membranes
Lipid rafts generate digital-like signal transduction in cell plasma membranes
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DOI：
10.1002/biot.201100360
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发表时间：
2012-06-01
影响因子：
4.7
通讯作者：
Suzuki, Kenichi G. N.
中科院分区：
文献类型：
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作者：
Suzuki, Kenichi G. N.
脂筏是介观尺度（5200 nm）的细胞膜结构域，信号分子在其中组装和发挥功能。然而，由于其动态性质，它一直难以解开的脂筏中的信号转导机制。最近先进的成像技术显示，信号分子经常，但短暂的，招募筏与蛋白质，蛋白质-脂质，和/或脂质-脂质相互作用的帮助。筏内的单个信号分子仅在短时间内被激活。通过细胞骨架肌动蛋白丝和支架蛋白固定信号分子可能有助于更有效地从筏传递信号。在这篇综述中，目前的意见如何在筏分子相互作用的瞬态性质产生的数字样信号转导细胞膜，这种现象提供的好处，进行了讨论。
Lipid rafts are meso-scale (5200 nm) cell membrane domains where signaling molecules assemble and function. However, due to their dynamic nature, it has been difficult to unravel the mechanism of signal transduction in lipid rafts. Recent advanced imaging techniques have revealed that signaling molecules are frequently, but transiently, recruited to rafts with the aid of protein-protein, protein-lipid, and/or lipid-lipid interactions. Individual signaling molecules within the raft are activated only for a short period of time. Immobilization of signaling molecules by cytoskeletal actin filaments and scaffold proteins may facilitate more efficient signal transmission from rafts. In this review, current opinions of how the transient nature of molecular interactions in rafts generates digital-like signal transduction in cell membranes, and the benefits this phenomenon provides, are discussed.