Interdependent adrenergic receptor regulation of Arc and Zif268 mRNA in cerebral cortex.
Interdependent adrenergic receptor regulation of Arc and Zif268 mRNA in cerebral cortex.
复制标题
大脑皮层中 Arc 和 Zif268 mRNA 的相互依赖的肾上腺素受体调节。
DOI：
10.1016/j.neulet.2015.12.002
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发表时间：
2016
影响因子：
2.5
通讯作者：
Sanders,Jeff
中科院分区：
文献类型：
--
作者：
Essali,Norah;Sanders,Jeff
去甲肾上腺素是一种神经递质，通过刺激α1、α 2和β肾上腺素能受体（AR）来传递信号。我们确定了这些受体在调节大鼠大脑皮层中的即刻早期基因、活性调节细胞骨架相关蛋白（ARC）和Zif 268中的作用。α2-AR拮抗剂RX 821002可使皮质层的Arc和Zif 268升高。接下来，我们检查了与α1-AR拮抗剂哌唑嗪和β-AR拮抗剂普萘洛尔一起递送RX 821002的作用。RX 821002与哌唑嗪和普萘洛尔混合物或单独与这些拮抗剂中的每一种一起给药，在大多数皮质层中将Arc和Zif 268降低至盐水处理的对照水平。当大鼠单独给予哌唑嗪和普萘洛尔鸡尾酒或单独给予这些拮抗剂时，Arc和Zif 268水平也与盐水处理的对照水平相似。综上所述，这些数据表明，与α 1和β-AR相比，α2-AR独特地对Arc和Zif 268施加紧张性抑制调节。然而，RX 821002增加Arc和Zif 268的能力与α 1和β-AR信号相互依赖。
Norepinephrine is a neurotransmitter that signals by stimulating the α1, α2and β adrenergic receptor (AR). We determined the role of these receptors in regulating the immediate early genes, Activity Regulated Cytoskeleton Associated Protein (Arc) and Zif268 in the rat cerebral cortex. RX821002, an α2-AR antagonist, produced Arc and Zif268 elevations across cortical layers. Next we examined the effects of delivering RX821002 with an α1-AR antagonist, prazosin, and a β-AR antagonist, propranolol. RX821002 given with a prazosin and propranolol cocktail, or with each of these antagonists individually, decreased Arc and Zif268 to saline-treated control levels in most cortical layers. Arc and Zif268 levels were also similar to saline-treated control levels when rats were given a prazosin and propranolol cocktail alone, or when each of these antagonists were delivered individually. Taken together, these data reveal that α2-AR uniquely exert a tonic inibitory regulation of both Arc and Zif268 compared to α1and β-AR. However, the ability of RX821002 to increase Arc and Zif268 is interdependent with α1and β-AR signaling.