Trichodermamides A and B, cytotoxic modified Dipeptides from the marine-derived fungus Trichoderma virens
Trichodermamides A and B, cytotoxic modified Dipeptides from the marine-derived fungus Trichoderma virens
复制标题
DOI：
10.1021/np0204390
复制
发表时间：
2003-03-01
影响因子：
5.1
通讯作者：
Clardy, J
中科院分区：
文献类型：
--
作者：
Garo, E;Starks, CM;Clardy, J
木霉A(1)和B(2)是从海洋来源的真菌绿色木霉的培养物中分离得到的两种修饰的二肽。毛霉胺具有一种罕见的环状O-烷基肟官能团，结合到一个六元环中。用X射线衍射法确定了毛霉胺B的结构，用光谱分析和化学方法确定了毛霉胺A的结构和绝对立体化学。木霉胺B对人结肠癌HCT-116细胞有明显的体外杀伤作用，IC50为0.32µg/mL。
Trichodermamides A (1) and B (2), two modified dipeptides, have been isolated from cultures of the marine-derived fungus Trichoderma virens. The trichodermamides possess a rare cyclic O-alkyl-oxime functionality incorporated into a six-membered ring. The structure of trichodermamide B was established by X-ray diffraction analysis, while the structure assignment of trichodermamide A, and determination of the absolute stereochemistry, was accomplished by spectral and chemical methods. Trichodermamide B displayed significant in vitro cytotoxicity against HCT-116 human colon carcinoma with an IC50 of 0.32 mug/mL.