Thyroid cancer in Luxembourg: a national population-based data report (1983-1999).
Thyroid cancer in Luxembourg: a national population-based data report (1983-1999).
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卢森堡的甲状腺癌：基于国家人口的数据报告（1983-1999）。
DOI：
10.1186/1471-2407-6-102
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发表时间：
2006-04-24
期刊：
影响因子：
3.8
通讯作者：
Capesius C
中科院分区：
文献类型：
--
作者：
Scheiden R;Keipes M;Bock C;Dippel W;Kieffer N;Capesius C
在切尔诺贝利核事故（东欧）发生20年后，关于放射性碘，特别是I-131对西欧甲状腺癌（TC）增加的可能影响，仍然存在争议。研究了卢森堡与其他欧洲国家相比TC发病率的时间趋势及其描述性流行病学。国家形态学肿瘤登记处收集了1983年至1999年在全国范围内中央病理科诊断的新发甲状腺癌的人口数据，并对TC的发病率进行了审查。1990年至1999年的数据被用来评估性别，年龄，组织学类型，肿瘤大小和结果的分布。在1990年至1999年诊断的310例新发甲状腺癌中，评价了304例分化癌（A：80%乳头状癌; B：14.5%滤泡状癌; C：3.5%髓样癌）和6例间变性/未分化TC（D：2%）。男/女比为1：3.2，平均年龄48.3岁（范围：13-92岁）。在1990-1994年和1995-1999年这两个五年期间，按年龄标准化的（世界人口）总发病率，女性从每100 000人7.4例增加到每100 000人10.1例，男性从每100 000人2.3例增加到每100 000人3.6例。仅3例患者为儿童或青少年（1%），大多数患者（50%）年龄在45 - 69岁之间。微小癌（<1cm）：A组46.4%（115/248），B组13.3%（6/45），C组27.3%（3/11）。1997年TC的意外增加主要是由于微小癌数量的增加。观察到的两种性别的5年生存率分别为A：96.0+/-2%; B：88.9%; C：90.9%; D：0%。年轻患者的预后良好，男性和老年患者的预后较差，未分化TC的预后极差。TC的发病率增加，尤其是乳头状型，似乎主要是由于在一定程度上由于组织学标准的变化和更有效的诊断工具，诊断微小癌的上升。这一增长似乎与手术治疗的数量、移民率和切尔诺贝利放射性尘埃无关，因为儿童TC的发病率保持稳定。
Twenty years after the nuclear accident in Chernobyl (Eastern Europe), there is still a controversial debate concerning a possible effect of the radioactive iodines, especially I-131, on the increase of thyroid carcinomas (TCs) in Western Europe. Time trends in incidence rates of TC in Luxembourg in comparison with other European countries and its descriptive epidemiology were investigated. The population-based data of the national Morphologic Tumour Registry collecting new thyroid cancers diagnosed between 1983 and 1999 at a nation-wide level in the central division of pathology were reviewed and focused on incidence rates of TC. Data from 1990 to 1999 were used to evaluate the distribution by gender, age, histological type, tumour size and the outcome. Out of 310 new thyroid carcinomas diagnosed between 1990 and 1999, 304 differentiated carcinomas (A: 80% papillary; B: 14.5% follicular; C: 3.5% medullary) and 6 anaplastic/undifferentiated TCs (D: 2%) were evaluated. The M/F-ratio was 1:3.2, the mean age 48.3 years (range: 13–92). The overall age-standardized (world population) incidence rates over the two 5-year periods 1990–1994 and 1995–1999 increased from 7.4 per 100,000 to 10.1 per 100,000 in females, from 2.3 per 100,000 to 3.6 per 100,000 in males. Only 3 patients were children or adolescents (1%), the majority of the patients (50%) were between 45 and 69 years of age. The percentage of microcarcinomas (<1 cm) was A: 46.4%, (115/248); B: 13.3%, (6/45); C: 27.3%, (3/11). The unexpected increase of TCs in 1997 was mainly due to the rise in the number of microcarcinomas. The observed 5-year survival rates for both genders were A: 96.0+/-2%; B: 88.9%; C: 90.9%; D: 0%. Prognosis was good in younger patients, worse in males and elderly, and extremely poor for undifferentiated TCs. The increasing incidence rates of TC, especially of the papillary type, seem mainly due to a rise in diagnosed microcarcinomas due to some extent to a change in histologic criteria and to more efficient diagnostic tools. This rise appears to be independent of the number of surgical treatments, the immigration rate, and the Chernobyl fallout as the incidence of TC in children remained stable.
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影响因子：
5.8
作者：
Leenhardt, L;Bernier, MO;De Vathairelo, F
通讯作者：
De Vathairelo, F
影响因子：
3.4
作者：
Bhattacharyya, N
通讯作者：
Bhattacharyya, N
影响因子：
8.4
作者：
Cotterill, SJ;Pearce, MS;Parker, L
通讯作者：
Parker, L
影响因子：
6.4
作者：
Lundgren, CI;Hall, P;Dickman, PW
通讯作者：
Dickman, PW
影响因子：
6.4
作者：
FURMANCHUK, AW;ROUSSAK, N;RUCHTI, C
通讯作者：
RUCHTI, C