ACTION OF HUMAN HIGH-DENSITY LIPOPROTEIN ON CHOLESTEROL CRYSTALS .1. LIGHT-MICROSCOPIC OBSERVATIONS
ACTION OF HUMAN HIGH-DENSITY LIPOPROTEIN ON CHOLESTEROL CRYSTALS .1. LIGHT-MICROSCOPIC OBSERVATIONS
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DOI：
10.1016/0021-9150(78)90142-9
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发表时间：
1978-01-01
期刊：
影响因子：
5.3
通讯作者：
ABDULLA, YH
中科院分区：
文献类型：
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作者：
ADAMS, CWM;ABDULLA, YH
在体外发现高密度脂蛋白 (HDL) 从洗涤的游离胆固醇晶体（商业或动脉粥样硬化来源）中形成髓鞘芽（脂质体）。这种活动导致晶体逐渐破坏和溶解。低密度脂蛋白和极低密度脂蛋白没有任何作用。 Ca 离子、磷脂酶 A 和多不饱和卵磷脂 (Lipostabil) 加速了脂质体的形成和溶解。与 HDL-Lipostabil 一起孵育 18 小时后，胆固醇晶体几乎完全被破坏。 [这对于动脉粥样硬化脂质的吸收和动脉粥样硬化的消退可能有价值]。
High density lipoprotein (HDL) was found in vitro to form myelin buds (liposomes) from washed crystals of free cholesterol (commercial or atheroma sources). This activity led to the progressive destruction and solubilization of the crystals. Low density and very low density lipoproteins did not have any effect. Liposome formation and solubilization were accelerated by Ca ions, phospholipase A and polyunsaturated lecithin (Lipostabil). Cholesterol crystals were nearly completely destroyed after 18 h incubation with HDL-Lipostabil. [This may be of value in relation to the resorption of atheroma lipids and the regression of atherosclerosis.].