Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer.
Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer.
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DOI：
10.1038/sj.bjc.6604884
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发表时间：
2009-02-10
影响因子：
8.8
通讯作者：
Orntoft, T. F.
中科院分区：
文献类型：
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作者：
Andersen, C. L.;Christensen, L. L.;Thorsen, K.;Schepeler, T.;Sorensen, F. B.;Verspaget, H. W.;Simon, R.;Kruhoffer, M.;Aaltonen, L. A.;Laurberg, S.;Orntoft, T. F.
本研究的目的是确定失调的转录因子（TF）在结直肠癌（CRC），并评估其与II期CRC的复发和总生存率的关系。使用20个正常粘膜和424个CRC样本的基于微阵列的转录谱来鉴定在正常粘膜和CRC之间显示差异转录水平的51个TF。对于其中的一个子集，我们提供了体外证据，证明Wnt信号通路的失调可以导致组织中观察到的改变。此外，在两个独立的微卫星稳定的II期癌症队列中，我们发现高SOX 4转录水平与复发相关（HR 2.7; 95%CI，1.2-6.0; P=0.01）。通过免疫组化分析1000例I-III期腺癌，发现肿瘤显示高水平CBFB和SMARCC 1蛋白的患者的总生存率（分别为P=0.0001和P=0.0275）明显优于低水平患者。多变量分析显示高CBFB蛋白水平是生存的独立预测因子。总之，几个确定的TF似乎参与了CRC的进展。
The aim of this study was to identify deregulated transcription factors (TFs) in colorectal cancer (CRC) and to evaluate their relation with the recurrence of stage II CRC and overall survival. Microarray-based transcript profiles of 20 normal mucosas and 424 CRC samples were used to identify 51 TFs displaying differential transcript levels between normal mucosa and CRC. For a subset of these we provide in vitro evidence that deregulation of the Wnt signalling pathway can lead to the alterations observed in tissues. Furthermore, in two independent cohorts of microsatellite-stable stage II cancers we found that high SOX4 transcript levels correlated with recurrence (HR 2.7; 95% CI, 1.2–6.0; P=0.01). Analyses of ∼1000 stage I–III adenocarcinomas, by immunohistochemistry, revealed that patients with tumours displaying high levels of CBFB and SMARCC1 proteins had a significantly better overall survival rate (P=0.0001 and P=0.0275, respectively) than patients with low levels. Multivariate analyses revealed that a high CBFB protein level was an independent predictor of survival. In conclusion, several of the identified TFs seem to be involved in the progression of CRC.
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影响因子：
64.8
作者：
Bartkova, J;Horejsi, Z;Bartek, J
通讯作者：
Bartek, J
DOI：
10.1083/jcb.200311021
发表时间：
2004-07-05
期刊：
The Journal of cell biology
影响因子：
--
作者：
Blache P;van de Wetering M;Duluc I;Domon C;Berta P;Freund JN;Clevers H;Jay P
通讯作者：
Jay P
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
20.3
作者：
Kundu, M;Chen, A;Liu, PP
通讯作者：
Liu, PP
影响因子：
56.9
作者：
He, TC;Sparks, AB;Kinzler, KW
通讯作者：
Kinzler, KW