The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people
The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people
复制标题
DOI：
10.1016/j.neulet.2006.07.055
复制
发表时间：
2006-10-09
影响因子：
2.5
通讯作者：
Shiels, Paul G.
中科院分区：
文献类型：
--
作者：
Harris, Sarah E.;Deary, Ian J.;Shiels, Paul G.
端粒是保护染色体末端的核蛋白复合物。体细胞每次复制时，端粒 DNA 成分都会缩短，最终导致细胞衰老。端粒长度与年龄相关疾病的发病率和死亡率有关。我们测试了以下假设：79 岁时的平均外周血白细胞端粒长度与 79 岁时的身体健康状况、79 岁时的认知能力、终生认知变化、吸烟、饮酒、成年期的社会阶层以及无痴呆人群的死亡率相关（Lothian Birth Cohort 1921：LBC 1921）。在 11 岁时心理能力调整之前（r = -0.16，p = 0.027）和之后（r = -0.17，p = 0.022），端粒长度和语言流畅性（执行功能测试）之间存在微小而显着的关联。这可能是 I 型错误。除此之外，我们发现老年端粒长度与年龄相关的身体和认知能力下降或死亡率没有显着相关性。 (c) 2006 Elsevier Ireland Ltd. 保留所有权利。
Telomeres are nucleo-protein complexes that protect the ends of chromosomes. The telomeric DNA component shortens each time a somatic cell replicates, eventually leading to cell senescence. Telomere length has been associated with morbidity and mortality rates from age-related diseases. We tested the hypotheses that mean peripheral blood leukocyte telomere length, at age 79 years, is associated with physical health at age 79, cognitive ability at age 79, lifetime cognitive change, smoking, alcohol consumption, social class in adulthood, and mortality in a cohort of people without dementia (the Lothian Birth Cohort 1921: LBC 1921). There was a small, significant association between telomere length and verbal fluency (a test of executive function) before (r = -0.16, p = 0.027) and after (r = -0.17, p = 0.022) adjustment for mental ability at age 11. This might be a type I error. Otherwise, we find that telomere length in old age does not have a significant association with age-related physical and cognitive decline or mortality. (c) 2006 Elsevier Ireland Ltd. All rights reserved.