Effect of quinolones on intestinal ecology
Effect of quinolones on intestinal ecology
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DOI：
10.2165/00003495-199958002-00013
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发表时间：
1999-01-01
期刊：
影响因子：
11.5
通讯作者：
Nord, CE
中科院分区：
文献类型：
--
作者：
Edlund, C;Nord, CE
喹诺酮类药物对正常人体肠道菌群有选择性作用。发表的13种喹诺酮类药物[环丙沙星、依诺沙星、诺氟沙星、氧氟沙星、培氟沙星、洛美沙星、左氧氟沙星、斯帕沙星、鲁氟沙星、西他沙星（DU-6859a）、加替沙星、曲瓦沙星和莫西沙星]的数据显示，在治疗过程中，革兰氏阴性需氧细菌，特别是肠杆菌科细菌被强烈抑制或消除。施他沙星和莫西沙星对革兰氏阳性需氧球菌有强烈影响，其他喹诺酮类药物对其影响较小。三种新的喹诺酮类药物——加替沙星、曲瓦沙星和莫西沙星对体外厌氧菌有很好的抑制作用，但对人体肠道厌氧菌群的影响很小。其他10种喹诺酮类药物也有类似的发现。因此，喹诺酮类抗菌药对人体肠道菌群（主要是肠杆菌）有生态影响，在使用这些药物预防或治疗胃肠道细菌感染时应考虑到这一点。
Quinolones have a selective effect on the normal human intestinal microflora. Published data on 13 different quinolone agents [ciprofloxacin, enoxacin, norfloxacin, ofloxacin, pefloxacin, lomefloxacin, levofloxacin, sparfloxacin, rufloxacin, sitafloxacin (DU-6859a), gatifloxacin, trovafloxacin and moxifloxacin] show that Gramnegative aerobic bacteria, especially Enterobacteriaceae, are strongly suppressed or eliminated during therapy. Gram-positive aerobic cocci are affected strongly by administration of sitafloxacin and moxifloxacin and to minor degrees by the other quinolones. Three new quinolones - gatifloxacin, trovafloxacin and moxifloxacin - are very active against anaerobic bacteria in vitro but have minor effects on the anaerobic intestinal human microflora. Similar findings have been reported for the other 10 quinolones. Thus, the quinolone antibacterials have an ecological impact on the human intestinal microflora, mainly on the enterobacteria, that should be taken into account when these agents are used for prophylaxis or treatment of gastrointestinal bacterial infections.