Silver-coated megaendoprostheses in a rabbit model - an analysis of the infection rate and toxicological side effects
Silver-coated megaendoprostheses in a rabbit model - an analysis of the infection rate and toxicological side effects
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DOI：
10.1016/j.biomaterials.2004.01.008
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发表时间：
2004-11-01
期刊：
影响因子：
14
通讯作者：
von Eiff, C
中科院分区：
文献类型：
--
作者：
Gosheger, G;Hardes, J;von Eiff, C
大型假体深度感染是骨科肿瘤手术的一个严重并发症。尽管使用了全身和局部抗生素预防，但报告的感染率在5%至35%之间。镀银医疗设备证明了它们在减少感染方面的有效性。本研究的目的是检查体内的抗菌功效和可能的副作用镀银巨型假体。在第一项研究中，30只兔子（15只钛和15只镀银的Mutarso-endoprostheses）感染了金黄色葡萄球菌。在第二项研究中，对10只兔子的毒理学副作用进行了分析。银组有显著性差异(p
Deep infection of megaprostheses remains a serious complication in orthopedic tumor surgery. Despite the use of systemic and local antibiotic prophylaxis the reported infection rate is between 5% and 35%. Silver-coated medical devices proved their effectiveness in reducing infections. The objective of this study was to examine in vivo the antimicrobial efficacy and possible side-effects of a silver-coated megaprosthesis. In a first study, 30 rabbits (15 titanium versus 15 silver-coated Mutarso-endoprostheses) were infected with Staphylococcus aureus. In a second study, toxicological side effects were analyzed in 10 rabbits with a silver-coated megaprosthesis.The silver group showed significantly (p