An ERP study of vocal emotion processing in asymmetric Parkinson's disease
An ERP study of vocal emotion processing in asymmetric Parkinson's disease
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DOI：
10.1093/scan/nss094
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发表时间：
2013-12-01
影响因子：
4.2
通讯作者：
Kotz, Sonja A.
中科院分区：
文献类型：
--
作者：
Garrido-Vasquez, Patricia;Pell, Marc D.;Kotz, Sonja A.
帕金森病（PD）与情绪语音语调（情绪韵律）加工受损有关。特发性PD的一个显著特征是运动症状不对称，纹状体功能障碍在最严重的身体一侧的对侧半球最为强烈。目前尚不清楚这种不对称是否会影响声音情绪感知。在此，我们在事件相关电位研究中测试了22名PD患者（10名主要为左侧[LPD]， 12名主要为右侧运动症状）和22名健康对照。表达不同情绪语调的句子以词汇和伪语音的形式呈现。任务在显性指令和隐性指令之间有所不同。特别有趣的是，从韵律中检测出的情绪显著性，反映在P200成分中。我们预测以右纹状体功能障碍（LPD）为主的患者会出现P200的改变。我们的研究结果支持这一假设。LPD患者P200波幅增强，厌恶韵律、愤怒外显加工和快乐韵律内隐加工出现特异性缺陷。词汇性言语主要受影响，而伪言语加工基本未受影响。患者P200振幅与左侧运动评分和不对称指数显著相关。这些数据表明PD患者的情绪显著性检测受到不对称神经元变性的影响。
Parkinson's disease (PD) has been related to impaired processing of emotional speech intonation (emotional prosody). One distinctive feature of idiopathic PD is motor symptom asymmetry, with striatal dysfunction being strongest in the hemisphere contralateral to the most affected body side. It is still unclear whether this asymmetry may affect vocal emotion perception. Here, we tested 22 PD patients (10 with predominantly left-sided [LPD] and 12 with predominantly right-sided motor symptoms) and 22 healthy controls in an event-related potential study. Sentences conveying different emotional intonations were presented in lexical and pseudo-speech versions. Task varied between an explicit and an implicit instruction. Of specific interest was emotional salience detection from prosody, reflected in the P200 component. We predicted that patients with predominantly right-striatal dysfunction (LPD) would exhibit P200 alterations. Our results support this assumption. LPD patients showed enhanced P200 amplitudes, and specific deficits were observed for disgust prosody, explicit anger processing and implicit processing of happy prosody. Lexical speech was predominantly affected while the processing of pseudo-speech was largely intact. P200 amplitude in patients correlated significantly with left motor scores and asymmetry indices. The data suggest that emotional salience detection from prosody is affected by asymmetric neuronal degeneration in PD.